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CAS No. : 63335-24-0
MCE 国际站:Malabaricone B
产品活性:Malabaricone B 是一种天然存在的植物酚类物质,是一种具有口服活性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂,IC50 为 63.7 µM。Malabaricone B 具有抗癌、抗菌、抗氧化和抗糖尿病活性。
研究领域:Metabolic Enzyme/Protease | Apoptosis
作用靶点:Glucosidase | Apoptosis
结构分类:酚类 | 多酚类 | 酮、醛、酸
来源:植物 | 肉豆蔻科 | 肉豆蔻
In Vitro: Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC50 = 8.1 μM), which is significantly better than that of curcumin (IC50 = 26.7 μM).
The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 µM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3.
Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans.
In Vivo: Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice.
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货号: HY-N8517
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