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CAS No. : 20725-03-5
MCE 国际站:Fustin
产品活性:Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 是一种有效的淀粉样 β (Aβ) 抑制剂。Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 可增加 Aβ (1-42) 诱导的乙酰胆碱 (ACh) 水平、胆碱乙酰转移酶 (ChAT) 活性和 ChAT 基因的表达。Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 降低 Aβ (1-42) 诱导的乙酰胆碱酯酶 (AChE) 活性和 AChE 基因表达。Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 增加毒蕈碱 M1 受体基因表达和毒蕈碱 M1 受体结合活性。Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 可用于阿尔茨海默氏病研究。
研究领域:Neuronal Signaling | GPCR/G Protein
作用靶点:Amyloid-β | mAChR | Cholinesterase (ChE)
结构分类:黄酮类 | 二氢黄酮醇
来源:植物 | 漆树科 | 光叶漆
In Vivo: Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior.
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression.
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice.
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