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CAS No. : 520-30-9
MCE 国际站:Norartocarpetin
产品活性:Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性,其抑制活性 IC50 值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性,其 IC50 值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。
研究领域:Metabolic Enzyme/Protease | GPCR/G Protein | MAPK/ERK Pathway | Apoptosis
作用靶点:Tyrosinase | Ras | Raf | MAPKAPK2 (MK2) | Apoptosis
结构分类:黄酮类 | 黄酮 | 结构分类
来源:植物 | 桑科
In Vitro: Norartocarpetin has strong mushroom tyrosinase inhibitory activity with an IC50 value of 0.47 μM.
Norartocarpetin (0-100 μM; 48 h) leds to dose-dependent cytotoxic effects in NCI-H460 cells and MRC-9 cells with IC50 values of 22 μM and 85 μM, respectively.
Norartocarpetin (0, 11, 22, and 44 μM; 24 h) led to blockade of Ras/Raf/MAPK signalling pathway.
Norartocarpetin (0, 11, 22, and 44 μM, 24 h) induced the apoptosis of the human lung carcinoma cells (NCI-H460).
Norartocarpetin (0, 11, 22, and 44 μM) leds to S-phase cell cycle arrest.
Norartocarpetin (22 μM; 24 h) leds to dose-dependent suppression of cell invasion.
Norartocarpetin (0, 11, 22, and 44 μM, 24 h) leds to significant inhibition of cell migration.
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