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CAS No. : 1966153-17-2
MCE 国际站:C-Type Natriuretic Peptide (CNP) (1-22), human TFA
产品活性:C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),是 CNP 的 1-22 片段,是一种利钠肽受体 B (NPR-B) 激动剂。C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) 抑制由生理激动剂组胺和 5-HT 刺激或直接由 Forskolin 刺激的 cAMP 合成。CNP 是一种有效的、内皮衍生的松弛剂和生长抑制因子。
研究领域:Others
作用靶点:Others
In Vitro: C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) (0.01, 0.1, 1, 10, 100, 1000 nM) increases cGMP production in CHO cells expressing human NPR-B in a concentration-dependent manner.
In Vivo: PK parameters of CNP immunoreactivity after a single intravenous administration of C-Type Natriuretic Peptide (CNP) (1-22), human:
Dose (nM/kg) | AUC0-∞ (pM·min/mL) | MRT0-∞ (min) | T1/2 (min) | CLtot (mL/min/kg) | Vdss (mL/kg) |
20 | 320±54 | 1.02±0.18 | 1.42±0.45 | 63.9±11.9 | 64.2±5.1 |
PK parameters of CNP immunoreactivity after a single subcutaneous administration of C-Type Natriuretic Peptide (CNP) (1-22), human:
Dose (nM/kg) | Cmax (pM/mL) | Tmax (min) | AUC0-∞ (pM·min/mL) | MRT0-∞ (min) | T1/2 (min) | BA (%) |
50 | 9.02±3.74 | 5.0±0.0 | 152±73 | 13.9±3.4 | 10.0±5.0 | 19±9 |
Each value represents the mean±SD of 3 rats. MRT=mean residence time, CL
tot=total clearance, T
1/2=half-life period, BA=bioavailability.
i.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide.
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