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CAS No. : 2810-21-1
MCE 国际站:Stepharine
产品活性:Stepharine 是天然的生物碱,可直接靶向 TLR4 (TLR4 抑制剂),结合 TLR4/MD2 复合体。Stepharine 具有抗衰老、抗病毒和抗高血压等活性。
研究领域:Immunology/Inflammation
作用靶点:Toll-like Receptor (TLR)
结构分类:生物碱 | 异喹啉类生物碱
来源:植物 | 其他科
In Vitro: Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells.
Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation.
Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro.
In Vivo: Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex.
相关产品:C29 | ODN 1018 | TLR7 agonist 5 | AN-3485 | ODN 2088 | TLR4/NF-κB/MAPK-IN-1 | TLR9-IN-1 | Complete Freund's adjuvant (CFA) | ODN 105871 | MC-Val-Cit-PAB-Amide-TLR7 agonist 4 | Monophosphoryl lipid A | β-D-Glucan | Poly (I:C):Kanamycin (1:1) (sodium) | ODN TTAGGG | Bropirimine | Polygalasaponin F | Chloroquine-d5 diphosphate | DB-3-291 | ODN 24888 | ODN 2216 | Agatolimod | Enpatoran hydrochloride | BBIQ | UC-1V150 | AZD8848 | ODN 105870 | CU-T12-9 | TLR7/8 agonist 7 | ODN 21158 | TH1020
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-N9347
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