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Visnagin

CAS No. : 82-57-5

MCE 国际站：Visnagin

产品活性：Visnagin 是一种抗氧化剂呋喃香豆素衍生物，具有抗炎特性，可用于缓解疼痛的研究。Visnagin 具有预防Cerulein 诱导的急性胰腺炎 (AP) 的潜力。Visnagin 在血管平滑肌中具有良好的血管扩张作用。

研究领域：Others

作用靶点：Others

结构分类：酮、醛、酸

来源：植物  |  唇形科  |  椴叶鼠尾草  |  植物  |  伞形科

In Vitro: Visnagin (10 µM; for 4, 8, 16, 24 h) induces CYP1A1 transcription in HepG2 cells.
Visnagin (10 µM; for 16 h) elevates CYP1B1 gene expression in an aryl hydrocarbon receptor (AHR)-dependent manner, whereas MNF (3’-methoxy-4’-nitroflavone; 20 µM; pre-treated for 1 h) successfully counteracted this induction. Visnagin also enhances PAI-2 transcription in an AHR-dependent manner.

In Vivo: Visnagin (10, 30, 60 mg/kg; ip; for 7 days) is effective in reducing plasma amylase and lipase levels and reduces Cerulein (50 μg/kg, six, hourly i.p. injections) induced oxidative stress in male Swiss albino mice (age: 6-8 weeks, weighing 20-25 g).
Visnagin dose dependently decreases the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuates the levels of nuclear p65-NFκB. Visnagin improves the antioxidant defence by improving Nrf2 expression and halts pancreatic inflammation by suppressing NFκB and nitrotyrosine expression in the acinar cells.

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货号: HY-N1082

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