MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:MPIF-1/CCL23 Protein, Human (P.pastoris, His)
MPIF-1/CCL23 蛋白, Human (P.pastoris, His), 一种 CC 趋化因子,对静息 T 细胞和单核细胞具有高度趋化性,通过与趋化因子受体 CCR1 结合,介导炎症、免疫反应,可以抑制髓系祖细胞形成以及具有一定的促癌作用。MPIF-1/CCL23 蛋白, Human (P.pastoris, His)是一种由 P. pastoris 表达的重组人 MPIF-1/CCL23 (R46-N120) 蛋白,C 端带有 his 标签。
Synonyms: C-C motif chemokine 23; CCL23; CKB-8; MIP-3; MPIF-1; SCYA23
Species: Human
Source: P. pastoris
研究背景:CCL23, also known as macrophage inflammatory protein 3 (MIP-3) and myeloid progenitor inhibitory factor 1 (MPIF-1), is a small cytokine of the CC chemokine family, identified in 1997 in a cDNA library derived from human aortic endothelial cells and located on human chromosome 17. ccl23 has some amino acid similarity to ccl15 and is the only chemokine with an alternative splice variant in which the amino-terminal amino acid is deleted. Due to selective splicing, CCL23 occurs in two forms, the shorter CCL23α/CKβ8 and the longer CCL23β/CKβ8-1. CCL23 is expressed in liver, lung, pancreas and bone marrow tissues and is released by the constitutive type of monocyte-derived dendritic cells. ccl23 acts as a chemokine and is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. ccl23 functions primarily in combination with the chemokine receptor CCR1, a transmembrane G protein-coupled receptor. CCL23 has been reported to have dose-dependent inhibitory activity against progenitors of the granulocyte and monocyte producing lineages in mouse and human bone marrow stem cell colony formation assays in vitro. In addition, CCL23 plays a role in bone formation and is a potent chemoattractant for osteoblast precursors but has no effect on fully differentiated osteoblasts or osteoclasts. ccl23 has some pro-oncogenic effects and induces angiogenesis by activating CCR1 on vascular endothelial cells.
蛋白编号:P55773 (R46-N120)
基因 ID:6368
产品分类:细胞因子和生长因子 | 趋化因子 | CC 趋化因子 | 趋化因子 CCL23
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CC Chemokines | CCL23
货号: HY-P77088
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。