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MCE 国际站:IL-4R Protein, Cynomolgus (HEK293, Fc)
IL-4R alpha 是 IL-4 和 IL-13 受体共有的 α 亚基,最初发现于白细胞中。IL-4R alpha 耦连于 JAK1/2/3-STAT6 通路,参与促进 Th2 分化。IL-4R alpha/CD124, Cynomolgus 由 825 个氨基酸 (M1-S825) 组成。IL-4R alpha/CD124 Protein, Cynomolgus (M1-R232) 由 HEK293 细胞表达,包括一个 III 型纤连蛋白结构域 (125-224 a.a) 和 C- 末端 hFc 标记。
Synonyms: Interleukin-4 receptor subunit alpha; IL4R alpha; IL4R; CD124
Species: Cynomolgus
Source: HEK293
研究背景:Interleukin-4R alpha (IL-4Rα), also known as CD124 and B cell stimulatory factor (BSF) receptor, is one of the anti-inflammatory cytokines, and highly expressed in activated T-cells.
IL-4R alpha participates in forming two interleukin receptors in different cell types. For the type I receptor, depends on IL-4R alpha binding IL-4 to recruit IL-2R gamma chain in immune cells. IL-2R gamma is the common subunit for a variety of interleukin receptors, involved in the stimulation of neutrophil phagocytosis by IL-15. For the type II receptor, depends on IL-4R alpha binding IL-4 to recruit IL-13R alpha 1 chain. IL-13R alpha 1 is an alternat accessory protein to the common cytokine receptor gamma chain in non-immune cells.
The sequence of amino acids in IL-4R alpha proteins is very different among different animals.
IL-4 R alpha generates a soluble form by alternate splicing or proteolysis, maintaining ligand binding properties and inhibiting IL-4 bioactivity. IL-4 R alpha soluble isoform 1 can be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
IL-4 R alpha plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis.
蛋白编号:G7Q0S7 (M1-R232)
基因 ID:/
产品分类:细胞因子和生长因子 | 白细胞介素 | 白介素-4 受体 | 白介素-4 受体 alpha | CD 抗原 | 巨噬细胞 CD 蛋白 | IL-4R alpha/CD124 | CD 抗原 | 上皮细胞 CD 蛋白 | IL-4R alpha/CD124 | CD 抗原 | 内皮细胞 CD 蛋白 | IL-4R alpha/CD124
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-4 Receptor | IL-4R alpha | CD Antigens | Macrophage CD Proteins | IL-4R alpha/CD124 | CD Antigens | Epithelial cell CD Proteins | IL-4R alpha/CD124 | CD Antigens | Endothelial cell CD Proteins | IL-4R alpha/CD124
货号: HY-P77009
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