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MCE 国际站:IL-18RAP Protein, Rhesus Macaque (HEK293, Fc)
IL-18 是一种多效性促炎细胞因子,参与诱导炎症介质、调节 NK 细胞和 T 细胞的细胞毒活性以及 Th1 和 Th2 细胞的分化和活化。IL-18 通过其特定的细胞表面受体 IL-18R 结合发出信号,IL-18R 包含两个亚基:IL-18Rα 和 IL-18Rβ。IL-18与质膜上的IL-18受体α(Rα) 和β(Rβ) 链形成信号复合物,诱导多种炎性细胞因子。IL-18R 复合物募集 IL-1R 激酶和 TNF 相关因子 6,诱导核因子 kβ 激酶磷酸化,随后激活核因子 kβ。IL-18R beta 敲低抑制 IL-18 驱动的 C57/BL6 小鼠肿瘤细胞转移。IL-18RAP Protein, Rhesus Macaque (HEK293, Fc) 是一种重组蛋白,C 端带有 Fc 标签,由 357 个氨基酸 (M1-R356) 组成,在 HEK293 细胞中表达。
Synonyms: Interleukin-18 receptor accessory protein; CDw218b; IL-1R7; IL-18R-beta; CD218b
Species: Rhesus Macaque
Source: HEK293
研究背景:IL-18R beta (interleukin-18 receptor beta, also known as IL18RAP) is the signal transducing chain of the IL-18R complex and is also a member of the IL-1R family. IL-18R beta is expressed on T-cells, NK cells and dendritic cells, but not commonly expressed in mesenchymal cells.
The amino acid sequence of human IL-18R beta protein has low homology for mouse IL-18R beta protein.
IL-18R beta is the receptor of IL-18. IL-18 forms a signaling complex by binding to the IL-18 alpha chain (IL-18Rα). The co-receptor, termed IL-18 receptor beta chain (IL-18Rβ), is recruited to form a high affinity complex. IL-18/IL-18Rα/IL-18Rβ ternary complex formation juxtaposes the intracellular Toll-Interleukin-1 receptor domains of IL-18Rα and IL-18Rβ. Then, the adaptor molecule myeloid differentiation factor 88 (MyD88) is recruited presumably with the aid of TRAM. MyD88 further interacts with IL-1 receptor associating kinase (IRAK) 4 and IRAK1/2 to form the large molecular assembly referred to as Myddosome, which subsequently activates IKK via TRAF6. Finally, the signal activates the NF-κB and mitogen-activated protein kinase pathways7, which upregulate the expression of various inflammatory cytokines.
IL-18R beta binds to IL-18 and IL-18 receptor alpha forms a signalling complex induces the expression of various inflammatory cytokines. IL-18R beta knockdown inhibits tumor cell metastasis.
蛋白编号:XP_001108108 (M1-R356)
基因 ID:712046
产品分类:细胞因子和生长因子 | 白细胞介素 | 白介素-18 受体 | 白介素-18 受体 β | CD 抗原 | NK 细胞 CD 蛋白 | CD218b/IL-18RAP | CD 抗原 | 内皮细胞 CD 蛋白 | CD218b/IL-18RAP
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-18 Receptor | IL-18RAP | CD Antigens | NK Cell CD Proteins | CD218b/IL-18RAP | CD Antigens | Endothelial cell CD Proteins | CD218b/IL-18RAP
货号: HY-P77408
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