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Moringin

CAS No. : 73255-40-0

MCE 国际站：Moringin

产品活性：Moringin 是一种有效的选择性 TRPA1 离子通道天然激动剂，EC₅₀ 为 3.14 μM。Moringin 不会激活或非常微弱地激活香草素体感通道 TRPV1、TRPV2、TRPV3 和 TRPV4，以及褪黑素冷却受体 TRPM8。Moringin 具有降血糖、抗菌、抗炎、抗癌和神经保护活性。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

结构分类：其他类  |  结构分类

来源：植物  |  辣木科  |  辣木

In Vitro: In SH-SY5Y human neuroblastoma cells, Moringin (16.4 µM; 24-72 h) significantly reduces SH-SY5Y cell growth in a time and concentration-dependent manner.
Moringin (1.64-8.2 μM; 24 h) increases the expression of p53, p21, and Bax at both the protein and transcriptional level in SH-SY5Y cells. Moringin significantly increases the gene expression of both caspase 3 and 9 and enhanced their cleavage, thereby initiating an intrinsic apoptotic cascade.
Moringin inhibits nuclear translocation of NF-κB.

In Vivo: In experimental autoimmune encephalomyelitis (EAE) mice, Moringin (10 mg/kg; intraperitoneally daily for 5 week) pretreatment normalizes the aberrant Wnt-β-catenin pathway, resulting in GSK3β inhibition and β-catenin upregulation, which regulates T-cell activation (CD4 and FoxP3), suppresses the main inflammatory mediators (IL-1β, IL-6, and COX2), through activation of PPARγ. Moringin increases antioxidant Nrf2 expression in EAE mice.

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