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MCE 国际站:ADAM12 Protein, Mouse (Baculovirus, His-Myc)
ADAM12 Protein, Mouse (Baculovirus, His-Myc) 是一种分解素和金属蛋白酶。ADAM12 在上皮癌中上调,并有助于增加肿瘤增殖、转移和内分泌抵抗。
Synonyms: Adam12; MltnaDisintegrin and metalloproteinase domain-containing protein 12; ADAM 12; EC 3.4.24.-; Meltrin-alpha
Species: Mouse
Source: Sf9 insect cells
Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
研究背景:ADAM12 (a disintegrin and metalloprotease) is upregulated in breast, prostate, ovarian, skin, stomach, lung and brain cancers. Human ADAM12 can be expressed as two alternately spliced variants: the membrane-associated ADAM12-L, and the shorter secreted ADAM12-S. Both isoforms are composed of pro-, metalloprotease, disintegrin and cysteine-rich domains respectively, and a non-homologous cytoplasmic tail. ADAM12-L has a transmembrane region. ADAM12 contributes to tumor progression and metastasis in both orthotopic and transgenic tumor models by promoting tumor cell proliferation, migration and invasion, inducing tumor cell resistance to apoptosis, promoting endocrine resistance and enhancing malignant tumor-stroma crosstalk.
蛋白编号:Q61824 (E206-G706)
基因 ID:11489
产品分类:酶和调节子 | 去整合素和金属蛋白酶 | 解整合素金属蛋白酶 12 | 酶和调节子 | 水解酶
Categories:Enzymes & Regulators | ADAMs/ADAMTSs | ADAM12 | Enzymes & Regulators | Hydrolases (EC 3)
货号: HY-P72061
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