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MCE 国际站:IFN-alpha 6/IFNA6 Protein, Human (His-Myc)
IFN-alpha 6 (IFNA6) 属于 I 型干扰素家族,由巨噬细胞产生而具有抗病毒活性。重组人 IFN-alpha 6/IFNA6 蛋白 (His-Myc) 含有 169 个氨基酸 (S21-E189),由 E. coli 细胞产生并带有 N 端 His 标签和 C 端 Myc 标签。
Synonyms: IFNA6Interferon alpha-6; IFN-alpha-6; Interferon alpha-54; Interferon alpha-K; LeIF K
Species: Human
Source: E. coli
研究背景:IFN-alpha 6 (IFNA6; IFN-α6), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia.
Type I interferons (IFNs) are produced early in response to viral infection and modulate adaptive immunity. IFN-alpha 6 involves in acute myocarditis and chronic cardiac inflammation inhibition, promotes systemic murine cytomegalovirus (MCMV) infection by reducing MCMV replication.
As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA6 protein of human is very different from mouse (56.61%)
蛋白编号:P05013 (S21-E189)
基因 ID:3443
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素 α | 干扰素 α6
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-alpha | IFN-alpha 6
货号: HY-P72244
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