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MCE 国际站:IL-2R beta/CD122 Protein, Human (Biotinylated, HEK293, His-Avi)
IL-2R beta (CD122),一种表达于 T 淋巴细胞上的 Ⅰ 型细胞因子受体,是 IL-2 的受体。IL-2R beta 可介导 T 细胞免疫反应,如刺激 T 细胞增殖、激活淋巴因子激活的杀伤细胞。IL-2R beta/CD122 Protein, Human (Biotinylated, HEK293, His-Avi) 是一种由 HEK293 细胞产生的、生物素化的重组人 IL-2R beta 的胞外片段 (A27-D239),其 C 末端带有 6*His 标签和 Avi 标签。
Synonyms: IL-2R beta; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; igh affinity IL-2 receptor subunit beta; CD122
Species: Human
Source: HEK293
研究背景:IL-2R beta (CD122) is a type I cytokine receptor, and belongs to Type 4 subfamily. IL-2R beta is also a key component of the IL-15 receptor. IL-2R beta is broadly expressed in spleen, blood, and lymph node, such as B and T lymphocytes.
The sequence of amino acids in IL-2R beta differs in different species. Human IL-2R beta shares <60% aa sequence identity with mouse and rats.
IL-2R beta cytoplasmic domain heterodimerizes with IL-2 and leads to the activation of signaling pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAP kinase, and the JAK-STAT pathways. IL-2R beta binds IL-2 with intermediate affinity. IL-2R beta mediates IL-2 internalization and signal transduction, such as cell proliferation or differentiation. IL-2R beta interacts with IL-2 and increases the proportion of CD4+ T lymphocytes. IL-2R stimulates T cell proliferation and activating lymphokine-activated killer cells.
IL-2R beta mediates T cell immune responses, and also mediates endocytosis, as well as transducing the mitogenic signals of IL-2.
蛋白编号:P14784 (A27-D239)
基因 ID:3560
产品分类:细胞因子和生长因子 | 白细胞介素 | 白介素-2 受体 | 白介素-2 受体 beta | CD 抗原 | NK 细胞 CD 蛋白 | CD122/IL-2R beta | 生物素标记蛋白
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-2 Receptor | IL-2R beta | CD Antigens | NK Cell CD Proteins | CD122/IL-2R beta | Biotinylated Proteins
货号: HY-P72386
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