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MCE 国际站:SMAD5 Protein, Mouse (sf9)
SMAD5 (dwarfin C, JV5-1, MAD5) 是一种受体激活的 Smad (R-Smad),属于 dwarfin/SMAD 家族。SMAD5 蛋白受到 I 型 TGF-β 受体激活,而与 SMAD4 结合形成三聚体活性形式。SMAD5 参与 BMP 信号通路,调控成骨过程,与胚胎发育有关。SMAD5 能够上调 Runx2 表达,靶向骨钙素和碱性磷酸酶 (ALP) 而发挥功能。 SMAD5 Protein, Mouse (sf9) 全长 464 个氨基酸,由 sf9 昆虫细胞表达,不带标签。
Synonyms: Mothers against decapentaplegic homolog 5; Dwarfin-C; SMAD 5
Species: Mouse
Source: Sf9 insect cells
研究背景:SMAD5 is a receptor activated Smad (R-Smad), also known as dwarfin C, JV5-1 and MAD5, which belong to the dwarfin/SMAD family. The SMAD5 protein consists of an N-terminal domain responsible for DNA binding, a C-terminal domain primarily used for protein-protein interactions, and a junction region containing moths necessary for ubiquitination degradation. SMAD5 is activated by an activated type I TGF-β receptor, and phosphorylated SMAD5 binds to SMAD4 (common SMAD) to form heterotrimer complexes that enter the nucleus as transcription factors. At the same time, SMAD4 is also bound by inhibitory SMAD (SMAD6 and SMAD7), making R-Smad compete for receptors or interact with Smad4, and target degradation and negative regulation of TGF-β signaling. SMAD5 mainly responds to BMP signaling pathways. During embryonic development, SMAD5 is widely expressed in mice from gastrum formation. During this period, the loss of SMAD5 leads to mutations in the embryo, or defects in the yolk sac outside the embryo, and death in the second trimester. Furthermore, the BMP/SMAD5 pathway can regulate osteogenesis by up-regulating transcription of the transcription factor Runx2, or by targeting multiple cis-acting promoter elements in osteogenic specific genes, including osteocalcin and alkaline phosphatase (ALP). Alps bind to Smad interacting protein 1 (SIP1) and inhibit Smad5-induced SIP1 activation. A significant expansion of primitive multipotent progenitor cells showing normal terminal maturation was reported in embryonic stem cells from Smad5-deficient mice, suggesting that conditional activation or deactivation of Smad5-specific signaling pathways may contribute to hematopoietic and osteogenic tissue engineering.
蛋白编号:P97454 (T2-S465)
基因 ID:17129
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | Smad 家族 | SMAD5
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Smad Family | SMAD5
货号: HY-P74540
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