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BMP-3B/GDF10 Protein, Human

MCE 国际站：BMP-3B/GDF10 Protein, Human

骨形态发生蛋白 3 (BMP-3; GDF10) 是一种多效性配体蛋白，属于 TGFβ 家族。BMP-3 是成骨素的主要成分，具有成骨活性。BMP-3 在致癌过程中发挥抑制作用，通过 ActRIIB/SMAD2 依赖性和 TAK1/JNK 信号通路抑制结肠肿瘤的发生。重组人 BMP-3B/GDF10 蛋白全长 110 个氨基酸 (Q369-R478)，由 E. coli 大肠杆菌表达。

Synonyms: rHuBMP-3B; BIP; BMP-3B; GDF-10

Species: Human

Source: E. coli

研究背景：Bone Morphogenetic Protein 3 (BMP-3) is a ligand protein with pleiotropic, belongs to TGFβ family. BMP-3 is a major component of osteogenin, which has osteogenic activity. BMP-3 is widely found in different animals, while the sequence in human is lowly similar to Rat (81.94%), and mouse (80.86%).
BMP-3 particularly serves as a reliable biomarker for screening colorectal cancer (CRC) because BMP-3 is hypermethylated and its protein expression is significantly reduced in cancer cell lines.
BMP-3 also plays a suppressor role in carcinogenesis, suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways.
BMP-3 could exert two-way regulatory effects on activin signaling in distinct cell types. BMP-3 stimulates proliferation of human mesenchymal stem cells which could be blocked by TGF-β/activin receptor kinase inhibitors.
BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development. And BMP/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms.

蛋白编号：P55107 (Q369-R478)

基因 ID：2662

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  骨形态发生蛋白  |  生长分化因子 10

Categories：Cytokines and Growth Factors  |  TGF-beta Superfamily  |  Bone Morphogenetic Proteins (BMPs)  |  BMP-3B/GDF10

货号: HY-P7332

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