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NAP-2/CXCL7 Protein, Mouse (74a.a, His)

MCE 国际站：NAP-2/CXCL7 Protein, Mouse (74a.a, His)

CXCL7 (也称为中性粒细胞激活肽 2，NAP-2) 是一种血小板衍生的生长因子，属于ELR⁺ CXC 趋化因子家族，通过与其受体 CXCR2 结合，发挥有效的中性粒细胞趋化剂和激活剂的作用。NAP-2/CXCL7 Protein, Mouse (74a.a, His) 在大肠杆菌中表达产生，由 74 个氨基酸 (K40-Y113) 组成，并在 N 末端带有 His 标签。

Synonyms: C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

Species: Mouse

Source: E. coli

研究背景：CXCL7 is an important chemoattractant cytokine, which signals through binding to its receptor CXCR2. Many cells, including leucocytes and stromal cells, express CXCL7. CXCL7 is a potent chemoattractant and activator of neutrophil function.
CXCL7, a member of the CXC chemokine subfamily, is translated as a proprotein and cleaved into several smaller forms, each with particular functions. In humans, the CXCL7 gene is translated as a 14 kDa proprotein, designated leucocytederived growth factor (LDGF), which is cleaved into several smaller forms, platelet basic protein (PBP), connective tissue activating protein III (CTAP-III) and β-thrombogulin (β-TG), and NAP-2. The longest form, PBP or LDGF, is expressed in platelets and megakaryocytes and is reported to be a fibroblast mitogen. CTAP-III is a 85 amino acid protein and can be converted to 70 amino acid NAP-2 by enzymatic removal of 15 residues. CTAP-III is suggested to support megakaryocyte maturation and platelet production and is involved in resistance to mycobacteria by augmenting reactive oxygen production. NAP-2, the smallest protein in this series, is a neutrophil-activating mediator, stimulating functions such as lysosomal enzyme degranulation, but is reported to inhibit megakaryocytopoiesis.
CXCL7 has been demonstrated to participate in a variety of cellular processes, such as DNA synthesis, glycolysis, mitosis, intracellular cAMP accumulation, prostaglandin E2 secretion, as well as the synthesis of hyaluronic acid and plasminogen activator. Moreover, it is also an antimicrobial protein with bactericidal and antifungal activity. Recently, CXCL7 has been found to be deregulated in human cancers, and plays a role in tumor growth. For instance, CXCL7 is found to promote the growth of clear cell renal cell carcinoma. The CXCL7/CXCR2 signaling plays a promoting role in several common malignancies, including lung, renal, colon, and breast cancer.

蛋白编号：Q9EQI5 (K40-Y113)

基因 ID：57349

产品分类：细胞因子和生长因子  |  趋化因子  |  CXC 趋化因子  |  CXC 趋化因子配体 7

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CXC Chemokines  |  CTAP-III/CXCL7

货号: HY-P75698

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