MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:ACVR1 Protein, Mouse (HEK293, His-hFc)
Activin A receptor, type I (ACVR1),也称为 ALK-2,是一种骨形态发生蛋白 (BMP) I 型受体。ACVR1 参与多种生物过程,包括骨骼、心脏、软骨、神经和生殖系统的发育和调节。ACVR1 Protein, Mouse (HEK293, His-hFc) 在 HEK293 细胞中表达产生,由 123 个氨基酸(M1-E123) 组成,在 C 末端带有 His 和 Fc 标签。
Synonyms: Activin receptor type-1; ACTR-I; SKR1; TSR-I; TSK-7L; Acvrlk2; Tgfb1
Species: Mouse
Source: HEK293
Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
研究背景:Activin A receptor type I (ACVR1) gene, also known as ALK-2, is located in chromosome 2q23-q24 and encodes for the 509 amino acid protein. The ACVR1 protein product is initially described as an activin type I receptor, and it is found to be expressed in several tissues and different human cell lines.
The sequence of amino acids in ACVR1 proteins from different species is very stable, which leads to the conclusion that in the process of evolution, ACVR1 has been only slightly altered, and that both in humans and in animals, its function is similar.
As a member of the BMP/TGFβ receptor family, the ACVR1 protein contains an extracellular N-terminal ligand-binding domain, a transmembrane (TM) domain, an intracellular glycine-serine-rich (GS) domain, and a protein kinase (PK) domain. The loop positioned in the helix-loop-helix of the GS domain contains the key residues responsible for ACVR1 activation upon phosphorylation. As a type I receptor, ACVR1 forms heterotetrameric receptor complexes with the type II receptors BMPR2, ACVR2A, and ACVR2B. Such complexes consist of two type I and two type II receptors. Upon binding of ligands to the heteromeric complexes, type II receptors transphosphorylate the GS domain of type I receptors. As a result, the kinase domain of type I receptors is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. ACVR1 is first described to bind to activin A, a member of the BMP/TGFβ family that usually triggers phosphorylation and activation of SMAD2/3 upon complex formation with type II receptors. Later, ACVR1 is also found to bind several BMPs with distinct affinities, triggering SMAD1/5/8 signalling. Besides canonical SMAD signalling, ACVR1 can activate non-canonical signalling pathways, such as p38 mitogen-activated protein kinases/MAPKs.
ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP). ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system. More recently, ACVR1 has been experimentally validated as a cancer driver gene in diffuse intrinsic pontine glioma (DIPG).
蛋白编号:P37172 (M1-E123)
基因 ID:11477
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | Activin/Inhibins Receptor | 激活素受体 IA | 受体蛋白 | 受体丝氨酸/苏氨酸激酶 | 激活素受体 IA | 酶和调节子 | 丝氨酸/苏氨酸蛋白激酶 | 激活素受体 IA
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Activin/Inhibins Receptor | ALK-2/ACVR1 | Receptor Proteins | Receptor Serine/Threonine Kinases | ALK-2/ACVR1 | Enzymes & Regulators | Serine/Threonine Kinase Proteins | ALK-2/ACVR1
货号: HY-P75539
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。