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MCE 国际站:ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc)
ACVR2A,也称为激活素 RIIA,是一种激活素 II 型受体。在配体结合时,ACVR2A 可以形成由两种 II 型和两种I 型跨膜丝氨酸/苏氨酸激酶组成的受体复合物。ACVR2A 是 Activin A、Activin B 和Inhibin A 的受体。ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc) 在 HEK293 细胞中产生,由 134 个氨基酸(M1-P134) 组成,在 C 末端带有 His 和 Fc 标签。
Synonyms: ACVR-2A; Activin receptor type 2A; ACTR-IIA; ACVR2
Species: Mouse
Source: HEK293
Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
研究背景:ACVR2A is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A.
The sequence of amino acids in ACVR2A proteins from different species is very stable, which leads to the conclusion that in the process of evolution, ACVR2A has been only slightly altered, and that both in humans and in animals, its function is similar.
Signaling by activins and BMPs is highly promiscuous, since apart from signaling through ALK4/7, the activin type II receptors (ACVR2A and 2B) can interact also with several type I BMP receptors (ALK1/2/3/6), which can also form complexes with the type II BMP receptor, BMPRII. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ACVR2A can form complexes with different type I receptors that signal either to Smad2/3 (ALK4) or to Smad1/5/8 (ALK2, ALK3, ALK6). The different type I receptors compete for binding to ACVR2A and that this competition provides a mechanism that balances signaling between Activin A-mediated, ALK4-dependent Smad2/3 signaling, and BMP-mediated ALK2 or ALK3-dependent signaling to Smad1/5/8. In myeloma cells, BMP-6- and BMP-9-induced activation of SMAD1/5/8 through ACVR2A/ACVR2B/ALK2 is inhibited by activin A treatment.
蛋白编号:P27038 (M1-P134)
基因 ID:11480
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | Activin/Inhibins Receptor | 激活素受体 ⅡA | 受体蛋白 | 受体丝氨酸/苏氨酸激酶 | 激活素受体 ⅡA | 酶和调节子 | 丝氨酸/苏氨酸蛋白激酶 | 激活素受体 ⅡA
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Activin/Inhibins Receptor | Activin A Receptor Type 2A (ACTR-IIA) | Receptor Proteins | Receptor Serine/Threonine Kinases | Activin A Receptor Type 2A (ACTR-IIA) | Enzymes & Regulators | Serine/Threonine Kinase Proteins | Activin A Receptor Type 2A (ACTR-IIA)
货号: HY-P75562
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