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MCE 国际站:IL-17RB Protein, Human (289a.a, HEK293, His)
IL-17RB(白细胞介素 17 受体 B)是一种由 IL17RB 基因编码的蛋白质,是促炎细胞因子 IL-17B 和 IL-17E 的受体。IL-17RB 在肾脏、胰腺、肝脏、大脑和肠道中的表达较高。IL-17RB 可能在造血细胞分化和生长中发挥作用。IL-17RB 与炎症性疾病和癌症有关。IL-17RB Protein, Human (289a.a, HEK293, His) 由 HEK293 细胞表达,由 289 个氨基酸(M1-G289) 组成,在 C 末端带有 His 标签。
Synonyms: Interleukin-17 receptor B; IL-17RB; IL-17Rh1; IL-17B receptor; CRL4; EVI27
Species: Human
Source: HEK293
研究背景:IL-17RB (Interleukin 17 receptor B), a 47.9 kDa transmembrane protein (462 aa) that belongs to the IL-17 receptor family, and can be activated by IL-17B. It has been proved to be involved in inflammatory diseases and cancers. IL-17RB is expressed in various endocrine tissues and in epithelial cells in different organs such as kidney and liver and mucosal tissues.
The amino acid sequence of human IL-17RB protein has low homology with mouse IL-17B protein.
IL-17RB has a SEFIR cytoplasmic domain implicated in homotypic dimerization and recruitment of signaling proteins (shared with IL-17RA) and a TRAF6-binding domain (not found in IL-17RA). IL-17B shares its receptor IL-17RB with IL-17E (also known as IL-25) that binds to the heterodimeric IL-17RA/IL-17RB complex. The binding affinity (KD) of IL-17B for IL-17RB is around 30-fold lower than that of IL-17E. It does not bind IL-17, IL-17C and IL-17F. Interleukin-17 (IL-17) plays a pivotal role in inflammatory diseases and cancers. IL-17 acts its role through IL-17 receptor (IL-17R). The IL-17R family are single transmembrane proteins that include the subtype receptors of IL-17RA to IL-17RE. Upon ligand binding, IL-17RB activates the canonical NK-κB pathway as well as ERK, JNK, and p38. Moreover, TRAF6 binds to IL-17RB independently of its ligand and participates in IL-17RB-dependent NF-κB activation.
It is reported that IL-17RB expression is significantly increased in gastric cancer tissues. Moreover, overexpression of IL-17RB is strongly associated with metastasis and inversely correlates with progression-free survival in pancreatic cancer. IL-17RB can enhance thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression. By using a rodent ortholog of IL-17BR as a probe, IL-17BR message was found to be drastically up-regulated during intestinal inflammation elicited by indomethacin treatment in rats. IL-17RB expression in human innate type 2 lymphocytes, natural killer T (NKT) cells, and Th2 cells suggests a potential role in immune cells.
蛋白编号:Q9NRM6 (M1-G289)
基因 ID:55540
产品分类:细胞因子和生长因子 | 白细胞介素 | 白介素-17 受体 | 白介素-17 受体 B
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-17 Receptor | IL-17RB
货号: HY-P76420
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