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MCE 国际站:BMP-5 Protein, Human (HEK293, hFc)
骨形态发生蛋白 5 (BMP-5) 是一种多效性的配体蛋白,属于 TGFβ 家族,主要在肺和肝中表达。BMP-5 沉默后能下调 p38/ERK 信号通路活性抑制软骨细胞衰老和凋亡以及膝关节炎 (OA)。BMP-5 通过与 I 型受体 BMPR1A 和 II 型受体 BMPR2 结合,启动典型 BMP 信号级联,或通过 MAPK p38 信号级联等非典型途径触发信号,促进软骨分化。人 BMP-5 蛋白全长 454 个氨基酸 (M1-H454),具有 4 个糖基化序列。重组人 BMP-5 蛋白 (HEK293, hFc) 全长 131 个氨基酸 (Q324-H454),由 HEK293 细胞表达,带有 N 端 hFc 标签。
Synonyms: Bone morphogenetic protein 5; BMP-5
Species: Human
Source: HEK293
研究背景:Bone Morphogenetic Protein 5 (BMP-5) is a ligand protein with pleiotropic, belongs to TGFβ family and expresses mainly in the lung and liver. BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development. And BMP/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms.
BMP-5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis (OA) progression by downregulating activity in the p38/ERK signaling pathway.
BMP-5 initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2.
BMP-5 also triggers signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation.
BMP-5 specific expressing in neural crest progenitor cells is sufficient to induce cell proliferation through the MEK-ERK-ID3 signaling cascade, whereas disruption of this signaling cascade had no effect on cell survival.
蛋白编号:NP_066551.1 (Q324-H454)
基因 ID:653
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 骨形态发生蛋白 | 骨形态发生蛋白 5
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Bone Morphogenetic Proteins (BMPs) | Bone Morphogenetic Protein 5
货号: HY-P75472
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