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MCE 国际站:IFN-alpha 4/IFNA4 Protein, Human (P.pastoris, His)
IFN-alpha 4 (IFNA4) 属于 I 型干扰素家族,由巨噬细胞产生而具有抗病毒活性。重组人 IFN-alpha 4/IFNA4 蛋白 (P.pastoris, His) 含有 166 个氨基酸 (C24-D189),由 P. pastoris 酵母细胞产生并带有 C 端 His 标签。
Synonyms: Interferon alpha-4; Interferon alpha-76; IFNA4
Species: Human
Source: P. pastoris
研究背景:IFN-alpha 4 (IFNA4; IFN-α4), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia.
IFN-alpha 4 is the subtypes dominates in IFN-alpha, whose the response with IFNA5, IFNA7, and IFNA14 accounting for up to 85% of the subtypes expressed by Peripheral blood mononuclear cells (PBMCs).
IFN-alpha 4 is promoted by interferon (IFN) regulatory factors (IRFs), especially IRF-1 and IRF-7. And it exhibits function by inhibiting virus RNA replication and enhances human natural killer cytotoxicity against virus.
As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA4 protein of human is very different from mouse (57.07%) and rat (57.98), respectively.
蛋白编号:P05014 (C24-D189)
基因 ID:3441
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素 α | 干扰素 α4
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-alpha | IFN-alpha 4
货号: HY-P75823
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