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MCE 国际站:IFN-alpha 7/IFNA7 Protein, Human (P.pastoris, His)
IFN-alpha 7 (IFNA7) 属于 I 型干扰素家族,由巨噬细胞产生而具有抗病毒活性。重组人 IFN-alpha 7/IFNA7 蛋白 (P.pastoris, His) 含有 166 个氨基酸 (C24-D189),由 P.pastoris 酵母细胞产生并带有 C 端 His 标签。
Synonyms: Interferon alpha-7; IFN-alpha-7; Interferon alpha-J; LeIF J; IFN-alpha-J1
Species: Human
Source: P. pastoris
研究背景:IFN-alpha 7 (IFNA7; IFN-α7), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia.
IFNα-7 is identified as positive regulators that increases FOXP3 expression and/or decreases CTLA4 expression. Therefore, regulatory T cells (Tregs) as the key cells regulating peripheral autoreactive T lymphocytes, IFNα-7 regulates Treg functional states to protect Treg phenotype stabilization.
As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA7 protein of human is very different from mouse (58.73%)
蛋白编号:P01567 (C24-D189)
基因 ID:3444
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素 α | 干扰素 α7
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-alpha | IFN-alpha 7
货号: HY-P76405
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