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MCE 国际站:IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His)
IFN-alpha 1 (IFNA1) 属于 I 型干扰素家族,由巨噬细胞产生,具有抗病毒活性。IFN-alpha 1 参与了 JAK1/TYK2 通路,通过抑制病毒复制和调节免疫反应发挥作用。重组小鼠 IFN-alpha 1/IFNA1 蛋白 (P.pastoris, His) 由 P.pastoris 酵母细胞产生,带有 C 末端 His 标签。
Synonyms: IFNA1; IFNalpha 1; IFN-alpha 1
Species: Mouse
Source: P. pastoris
Biological Activity: Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV) and the ED50 is 20-100 pg/mL.
研究背景:IFN-alpha 1 (IFNA1; IFN-α1), belongs to the alpha/beta interferon family, is produced by macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
IFNs binds to one of three type-specific receptors, which leads to the activation of JAK1 and TYK2. This signal transduction results in phosphorylation of STAT1 and STAT2 and eventually in an association with IFN regulatory factor 9 (IRF9) and formation of the IFN-stimulated gene factor 3 (ISGF3) complex. Thus the ISGF3 complex induces transcription of IFN-stimulated genes (ISGs), with subsequent immunomodulatory effects on both innate and adaptive immune responses.
The interactions of type I IFN with the immune system is important for the generation of a durable antitumor response through its effects on dendritic cells (DC). IFN has been widely used for animal disease model, and the sequence of amino acids in IFNA1 protein of mouse is very different from human (62.96%).
蛋白编号:P01572 (C24-K189)
基因 ID:15962
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素 α | 干扰素 α1
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-alpha | IFN-alpha 1
货号: HY-P74866
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