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MCE 国际站:GITR Protein, Human (T45A, HEK293, mFc)
GITR (TNFRSF18) 是 TNFR 超家族的成员。GITR 促进 T 细胞活化和增殖,增加对肿瘤和病毒感染的抵抗力,并加剧自身免疫性疾病和炎症过程。GITR Protein, Human (T45A, HEK293, mFc) 是一种由 HEK293 细胞表达的重组蛋白,45 位的苏氨酸突变成了丙氨酸,其 C 末端带有 Fc 标签,由 136 (Q26-E161) 个氨基酸组成。
Synonyms: Tumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR
Species: Human
Source: HEK293
研究背景:GITR is expressed on regulatory T cells (Tregs) and some activated immune cells, including effector T lymphocytes, nature killer (NK) cells, and neutrophils.
The amino acid sequence of human GITR protein has low homology for mouse GITR protein.
GITR does not have any enzymatic activity and signaling is propagated via recruiting TRAF-family members, specifically TRAF1, TRAF2 and TRAF5, to the GITR-signaling complex. The signaling is then mediated through NF-kB and MAPK pathways. GITR does not have any enzymatic activity and signaling is propagated via recruiting TRAF-family members, specifically TRAF1, TRAF2 and TRAF5, to the GITR-signaling complex. The signaling is then mediated through NF-kB and MAPK pathways, protecting T cells from TCR activation-induced cell death.
GITR (Glucocorticoid-induced TNFR-related protein, also known as TNFRSF18) is a type I transmembrane protein. GITR stimulates the proliferation of effector T-lymphocytes and partially reverses the immunosuppressive function of CD4+CD25+ Tregs. GITR is activated by its ligand GITRL (TNFSF18). GITR induces NOS in murine macrophage in a time and dose-dependent manner. GITR inhibits Multiple Myeloma (MM) cell proliferation in vitro and in vivo and induces apoptosis.
蛋白编号:Q9Y5U5 (Q26-E161, T45A)
基因 ID:8784
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | 糖皮质激素诱导的肿瘤坏死因子受体 | CD 抗原 | 巨噬细胞 CD 蛋白 | GITR/CD357 | CD 抗原 | 单核细胞 CD 蛋白 | GITR/CD357 | 免疫检查点蛋白 | 刺激性免疫检查点
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | GITR | CD Antigens | Macrophage CD Proteins | GITR/CD357 | CD Antigens | Monocyte CD Proteins | GITR/CD357 | Immune Checkpoint Proteins | Stimulatory Immune Checkpoint Molecules
货号: HY-P70822
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