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MCE 国际站:TROY/TNFRSF19 Protein, Human (HEK293, Fc)
TROY 蛋白又称 TAJ、TNFRSF19,是一种 I 型跨膜受体,是 TNF 受体超家族的成员。TROY 蛋白参与胚胎发育以及皮肤和毛囊的发育。TROY 蛋白在体外抑制细胞增殖,并在异种移植模型中表现出抗肿瘤活性。重组人 TROY/TNFRSF19 蛋白 (HEK293, Fc) 是一种由 HEK293 细胞表达的重组蛋白,其 C 末端带有 Fc 标签,由 170 (M1-L1701) 个氨基酸组成。
Synonyms: Tumor necrosis factor receptor superfamily member 19; TRADE; TNFRSF19; TROY
Species: Human
Source: HEK293
研究背景:TROY Protein shows a unique tissue distribution in the embryo as well as after birth; in the embryo, TROY is exclusively expressed in the epithelium including the neuroepithelium, skin, bronchiolar epithelium, conjunctiva, and so forth, whereas after birth, TROY Protein is strongly expressed in hair follicles like Edar as well as in neurons. TROY Protein is expressed in several invasive cancers, including colorectal cancer, lung cancer, melanoma, nasopharyngeal carcinoma, prostate cancer and GBM.
The amino acid sequence of human TROY protein has low homology for mouse TROY protein.
TROY Protein is a growth-promoting signaling molecule that also regulates the NF-κB pathway via interacting with RKIP. In addition, increased TROY expression promotes STAT3 phosphorylation and STAT3 transcriptional activity that is dependent upon JAK1. TROY interacts with LGR5 and inhibits Wnt signaling.
Knock-down of TROY suppresses the growth of glioma cells and induces cell cycle arrest at the G1-S phase in U87 cells, significantly decreasing NF-kB luciferase activity. Increased TROY expression increases JAK1 phosphorylation, and silencing TROY expression inhibits GBM cell invasion, and increases sensitivity to temozolomide in glioblastoma.
蛋白编号:Q9NS68-2 (M1-L170)
基因 ID:55504
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | TROY 蛋白
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | TROY Protein
货号: HY-P73573
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