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MCE 国际站:CD40L/CD154/TRAP Protein, Canine (HEK293, Fc)
CD40L (CD154; TRAP) 是 CD40 (TNFRSF5) 的配体,在 T 细胞中产生共刺激信号而发挥上调 IL-4 合成的作用。CD40L 在活化的 CD4+ T 淋巴细胞上特异性表达,参与 NF-κB/MAPK 信号通路。CD40L 还参与 B 细胞的分化、成熟和凋亡。犬的 CD40L 蛋白可裂解为 2 种亚型,包括膜状肽 (1-260 a.a.) 和可溶性肽 (112-260 a.a.) (作为整合素的配体)。重组犬 CD40L/CD154/TRAP 蛋白 (HEK293, Fc) 全长 149 个氨基酸 (M112-L260),由 HEK293 细胞表达,带有 N 端 mFc 标签。
Synonyms: CD40 ligand; CD40-L; TRAP; CD154; sCD40L; TNFSF5
Species: Canine
Source: HEK293
研究背景:CD40 Ligand (CD40L; CD154; TRAP) belongs to the tumor necrosis factor (TNF) family, is the ligand for CD40/TNFRSF5, specifically expressed on activated CD4+ T-lymphocytes.
CD40L is a type II transmembrane protein on B cells triggers important signals for B cell differentiation, maturation, and apoptosis.
CD40L acts function by cross-linking on T-cells to generate a costimulatory signal and thus enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation, as well as promoting the production of interferon-γ, and TNF-α.
CD40L, binding with CD40 on antigen-presenting cells (APC), activates TNFR-associated factor 2- and IKK2-dependent pathways with stimulating I-κB kinase (IKK), increasing NF-κB DNA binding, and p65 nuclear translocation. The activation of I-κB kinase leads to strongly c-Jun N-terminal kinase activation as well as GST-I-κB and GST-p65 phosphorylation.
CD40L involves in MAPK pathways that strongly repress Bcl-6 with inducing the phosphorylation of Erk1/2, p38 and Jnk1/2 and activating IRF4 mediated by NF-κB.
CD40L also binds to and signals through several integrins, including αvβ3 and α5β1, which bind to the trimeric interface of CD40L. CD40L plays a major role in immune response and is a major target for inflammation.
蛋白编号:O97626 (M112-L260)
基因 ID:403468
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | CD40L 蛋白 | CD 抗原 | T 细胞 CD 蛋白 | CD40 Ligand/CD154 | CD 抗原 | 巨噬细胞 CD 蛋白 | CD40 Ligand/CD154 | 免疫检查点蛋白 | 刺激性免疫检查点
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | CD40 Ligand | CD Antigens | T Cell CD Proteins | CD40 Ligand/CD154 | CD Antigens | Macrophage CD Proteins | CD40 Ligand/CD154 | Immune Checkpoint Proteins | Stimulatory Immune Checkpoint Molecules
货号: HY-P75406
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