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MCE 国际站:TNFRSF3/LTBR Protein, Rat (HEK293, Fc)
TNFRSF3/LTBR Protein, Rat (HEK293, Fc) 是一种细胞凋亡和细胞因子释放的淋巴毒素的细胞表面受体,参与激活基因转录程序和细胞死亡,在免疫发育和宿主防御中非常重要。TNFRSF3/LTBR Protein, Rat (HEK293, Fc) 是由 HEK293 细胞表达的,是跨膜蛋白 (M222-W245),C 端带有 His 标签。
Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3
Species: Rat
Source: HEK293
研究背景:Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a member of the tumor necrosis factor receptor superfamily and a cell surface receptor for lymphotoxins involved in apoptosis and cytokine release. LTBR is expressed on the surface of most cell types, including breast, colorectal, lung, gastric, melanoma, and bladder cancers , while its ligands lymphotoxin (LT) a1b2 and TNF superfamily member 14 (TNFSF14; also known as LIGHT), are mainly expressed on the surface of immune cells. The LTBR signaling pathway may be involved in the activation of responses that control cell differentiation, growth and death, as manifested by the formation of peripheral lymphoid-like organs, especially secondary and tertiary lymphoid structures critical for tissue, dendritic cell homeostasis, liver regeneration, interferon response to pathogens and death in mucosa-derived carcinomas. LTβR signaling may facilitate communication between infiltrating immune cells and tumor cells. Triggering LTβR induces typical and atypical nuclear factor (NF)-κB signaling pathways that are associated with inflammation-induced oncogenic effects. Sustained LTβR signaling also leads to NF-κB-mediated chronic inflammation and the development of hepatocellular carcinoma (HCC).
蛋白编号:Q5U2S8 (M1-A218)
基因 ID:297604
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | 淋巴毒素-β 受体
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | Lymphotoxin β Receptor
货号: HY-P75917
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