MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:4-1BBL/TNFSF9 Protein, Rat (HEK293, His)
4-1BBL (4-1BB 配体) 是 TNF 超家族的 II 型膜蛋白,在抗原呈递细胞上表达。4-1BB 和 4-1BBL 可以诱导 T 细胞扩增、细胞因子诱导、分化和抗凋亡基因的上调以及保护 T 细胞免于活化诱导的细胞死亡 (AICD)。4-1BBL 刺激 T 细胞增殖并诱导有效的抗肿瘤免疫反应。4-1BBL 是一种免疫刺激分子,在抗原呈递过程中与 4-1BB 高亲和力受体相互作用,通过激活 NF-kB、c-Jun 和 p38 下游通路向 CD4+ 和 CD8+ T 细胞提供共刺激信号,触发对免疫系统的多效性影响。4-1BBL/TNFSF9 Protein, Rat (HEK293, His) 是一种由 HEK293 细胞表达重组蛋白,其 C 末端带有 His 标签,由 203 个 (P106-G308) 氨基酸组成。
Synonyms: Tumor necrosis factor ligand superfamily member 9; CD137L; 4-1BB Ligand
Species: Rat
Source: HEK293
研究背景:4-1BBL is expressed on a variety of antigen presenting cells (APCs), including activated B cells, dendritic cells, macrophages, and myeloid cells.
The amino acid sequence of human 4-1BBL protein has low homology for mouse and rat 4-1BBL protein.
4-1BBL binds to high-affinity 4-1BB, resulting in the recruitment of intracellular TRAF adaptor molecules (TRAF1 and TRAF2), and then activate of NF-jB and the extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 mitogen-associated protein (MAP) kinase signaling cascades. The binding of 4-1BBL to 4-1BB generates strong co-stimulatory signals in T-cells that lead to up-regulation of anti-apoptotic molecules, cytokine secretion, and enhanced effector function.
4-1BBL is a member of the TNF family of proteins. 4-1BBL is an immunostimulant molecule that interacts with the 4-1BB high-affinity receptor during the antigen presentation, providing costimulatory signals to both CD4+ and CD8+ T cells through the activation of NF-kB, c-Jun, and p38 downstream pathways, triggering pleiotropic effects on the immune system. 4-1BBL significantly induces T cell proliferation and increases the stimulation of both IL-2 and IFN-γ.
蛋白编号:Q80WE6 (P106-G308)
基因 ID:353218
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | 4-1BBL | CD 抗原 | 树突细胞 CD 蛋白 | 4-1BBL/CD137L | CD 抗原 | 上皮细胞 CD 蛋白 | 4-1BBL/CD137L | 免疫检查点蛋白 | 刺激性免疫检查点
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | 4-1BBL | CD Antigens | Dendritic Cell CD Proteins | 4-1BBL/CD137L | CD Antigens | Epithelial cell CD Proteins | 4-1BBL/CD137L | Immune Checkpoint Proteins | Stimulatory Immune Checkpoint Molecules
货号: HY-P76705
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。