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MCE 国际站:HCC-1/CCL14 Protein, Human
HCC-1/CCL14 Protein, Human是一种 CC 趋化因子,对人的单核细胞有较弱的活性,可促进单核细胞,嗜酸性粒细胞和T淋巴母细胞趋化性,可介导过敏性气道炎症和癌症。HCC-1/CCL14 Protein, Human 是一种由 E. coli 表达的重组人 HCC-1/CCL14(T22-N93)。
Synonyms: rHuHCC-1/CCL14; C-C motif chemokine 14; SCYA14
Species: Human
Source: E. coli
Biological Activity: 1.Fully biologically active whencompared to standard. The biological activity deter-mined by a chemotaxis bloassay using human mono-cytes is in a concentration of 5.0-20 ng/mL.
2.Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED50 this effect is 4.297 ng/mL, corresponding to a specific activity is 2.33×105 U/mg.
研究背景:CCL14, also known as HCC-1, is a human plasma chemokine originally collected and purified from the hemofiltrate of patients with chronic renal failure. CCL14 belongs to the small cytokine family of CC chemokines, a cluster of chemokines located on human chromosome 17 that can be expressed in a variety of tissues, including spleen, bone marrow, liver, muscle, and intestine. CCL14 has weak activity against human monocytes and no activity against T lymphocytes, neutrophils, and eosinophils. CCL14 is weakly active against human monocytes and inactive against T lymphocytes, neutrophils, and eosinophils.CCL14 acts as a protein precursor that requires protein hydrolysis to obtain receptor affinity and is processed to yield a mature active protein containing 74 amino acids. The processed HCC-1(9-74) is a chemokine that attracts monocytes, eosinophils and T cells and binds to CCR1, CCR3 and CCR5 chemokine receptors. Post-translational modifications of CCL14 chemokines, such as N-terminal truncation and glycosylation, also result in differential signaling compared to unmodified ones. For example, both full-length CCL14(1-74) and truncated isoform CCL14(9-74) bind to atypical chemokine receptor 2 (ACKR2), but only truncated CCL14(9-74) shows a propensity for β-restin and induces receptor internalization of ACKR2 compared to CCL14(1-74). Meanwhile, CCL14(1-74) was a weak agonist of chemokine receptor CCR1, but its activity was significantly enhanced after proteolytic cleavage to CCL14(9-74). CCL14 has been shown to inhibit HCC cell proliferation by inhibiting cell cycle progression and promoting apoptosis in hepatocellular carcinoma (HCC) cells.CCL14 inhibits HCC tumor growth in nude mice in vivo.CCL14 is also involved in the pathogenesis and progression of various diseases, including allergic airway inflammation and some cancers.
蛋白编号:Q16627 (T22-N93)
基因 ID:6358
产品分类:细胞因子和生长因子 | 趋化因子 | CC 趋化因子 | 趋化因子 CCL14
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CC Chemokines | CCL14
货号: HY-P7195
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