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MCE 国际站:DHH Protein, Human (C23II)
DHH Protein, Human是在 E. coli 中产生的一种非糖基化肽链。Desert hedgehog protein (DHH) 是 Hedgehog 家族成员,可编码信号分子,在调节形态发生中起重要作用。
Synonyms: rHuDHH; DHH; HHG-3
Species: Human
Source: E. coli
Biological Activity: Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. The ED50 this effect is 6.275 μg/mL, corresponding to a specific activity is 159.363 units/mg.
研究背景:Desert hedgehog (DHH) belongs to the hedgehog gene family that act as secreted intercellular signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and humans but is not present in the avian lineage. Like other hedgehog proteins, DHH signals through the patched (PTCH) receptors 1 and 2. The receptors PTCH1 and PTCH2 are highly conserved mediators of hedgehog signalling in both the developing and adult marsupial gonads. Together these findings indicate DHH is an essential therian mammal-specific morphogen in gonadal development and gametogenesis.
蛋白编号:O43323 (C23II & G24-G198)
基因 ID:50846
产品分类:其他
Categories:Others
货号: HY-P7338
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