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BCA-1/CXCL13 Protein, Mouse (HEK293, Fc)

MCE 国际站：BCA-1/CXCL13 Protein, Mouse (HEK293, Fc)

CXCL13，称为 BCA-1 (B 细胞吸引趋化因子 1) 或BLC (B 淋巴细胞趋化因子)，是一种通过与 BLR1/CXCR5 受体结合而对 B 淋巴细胞具有选择性的有效引诱剂。CXCL13 是一种稳态趋化因子，由次级淋巴组织（滤泡）的 B 细胞区域中的基质细胞组成型分泌，例如脾脏、淋巴结、扁桃体和派尔氏斑。BCA-1/CXCL13 Protein, Mouse (HEK293, Fc) 是在 HEK293 细胞中表达产生的，由 88 个氨基酸组成 (I22-A109)，并在 N 端带有 Fc 标签。

Synonyms: ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13

Species: Mouse

Source: HEK293

研究背景：CXCL13, also known as B lymphocyte chemoattractant, is originally identified in stromal cells in B cell follicles as regulating homing of B cells and subsets of T cells. CXCL13 plays a key role in orchestrating cell migration within spatially distinct regions of the secondary lymphoid organs. It strongly attracts B lymphocytes while promoting migration of only small numbers of T cells and macrophages. CXCL13 and its receptor, CXCR5, play fundamental roles in inflammatory, infectious, cancer and immune responses.
The amino acid sequence of human CXCL13 protein has low homology with mouse CXCL13 protein.
CXCL13 exerts its functions through its receptor CXCR5. CXCR5 is highly expressed on mature recirculating B-lymphocytes, a subpopulation of follicular helper T cells (TFH) and skin-derived migratory dendritic cells (DCs), and controls their migration into secondary lymphoid organs towards the gradient of CXCL13. As the loss of the BLR1/CXCR5 receptor is sufficient to disrupt organization of follicles in spleen and Peyer's patches, BCA-1 may act as a B cell homing chemokine. Human BCA-1 competes with radiolabeled IFN-γ inducible protein 10 (IP-10) for binding to the human CXCR3 receptor expressed in Ba/F3 and 293EBNA cell lines. Furthermore, human BCA-1 is an efficacious attractant for human CXCR3 transfected cells. BCA-1 does oes not induce calcium release in B-lymphocytes. In addition, human BCA-1 is an agonist in stimulating GTP gamma S binding. Human BCA-1 is a specific and functional G-protein-linked chemotactic ligand for the human CXCR3 receptor. CXCL13 has been widely implicated in the pathogenesis of a number of autoimmune diseases and inflammatory conditions, as well as in lymphoproliferative disorders. In addition, the CXCL13:CXCR5 axis orchestrates cell-cell interactions that regulate lymphocyte infiltration within the tumor microenvironment.
Dysregulation of the CXCL13:CXCR5 axis affecting both B- and TFH cell function is major player in autoimmune disorders, and potentially serves as a biomarker for disease progression and therapeutic response. Moreover, expression of CXCR5 and CXCL13 is shown to be dysregulated in HIV infection, such that the number of CXCR5+ B cells decreases with progression of HIV infection, together with an increase in plasma levels of CXCL13. CXCL13/CXCR5 signaling modulates cancer cell ability to grow, proliferate, invade, and metastasize. CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.

蛋白编号：O55038 (I22-A109)

基因 ID：55985

产品分类：细胞因子和生长因子  |  趋化因子  |  CXC 趋化因子  |  CXC 趋化因子配体 13

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CXC Chemokines  |  BCA-1/CXCL13

货号: HY-P77912

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