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MCE 国际站:ANGPTL8/Angiopoietin-like 8 Protein, Human (HEK293, Fc)
ANGPTL 8 Protein, Human (HEK293, Fc)是 LPL 的一种分泌抑制剂。Angiopoietin-like Protein 8可作为重要的代谢开关,与ANGPTL3或ANGPTL4形成复合物,引导甘油三酯在血液中的能量流动。
Synonyms: rHuAngiopoietin-like Protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like Protein 8
Species: Human
Source: HEK293
研究背景:Angiopoietin-like proteins (ANGPTLs) represent a family of eight secreted glycoproteins that show structural homology to angiopoietins and carry distinct physiological functions, including putative roles in lipid metabolism, expansion of stem cells, inflammation, tissue remodeling and angiogenesis. In recent years, three ANGPTLs, ANGPTL3, ANGPTL4 and ANGP-TL8, have been shown to play a role in lipid metabolism and in the regulation of plasma lipid levels. ANGPTL4 and ANGPTL8 form a complex when refolded together and that ANGPTL4 in that complex loses its ability to inactivate LPL. We have observed that the C-terminal helix of ANGPTL8 is important for complex formation with ANGPTL3 or ANGPTL4, rather than for covering the functional site of the protein, as was previously proposed.
蛋白编号:Q6UXH0 (A22-A198)
基因 ID:55908
产品分类:细胞因子和生长因子 | 血管生成素家族 | 血管生成素样蛋白 8
Categories:Cytokines and Growth Factors | Angiopoietins | Angiopoietin-Like 8
货号: HY-P7506
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