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MCE 国际站:RANK L/TNFSF11 Protein, Human (HEK293, Fc)
RANKL (TNFSF11),一种 II 型跨膜蛋白,是 NF-κB (RANK) 受体的配体。RANKL 是 NF-κB 的激活剂。当与 NF-κB 结合后,其诱导单核细胞/巨噬细胞谱系细胞分化为破骨细胞,并进一步导致破骨细胞前体成熟。因此,RANKL 对于破骨细胞成熟、骨骼建模和骨骼重塑,以及淋巴结 (LN) 的发育至关重要。RANKL/TNFSF11 Protein, Human (HEK293, Fc) 是一种由 HEK293 产生的重组人RANKL (G63-D244),N 端带 mFc 标签。
Synonyms: Tumor necrosis factor ligand superfamily member 11; ODF; RANKL; CD254; TNFSF11
Species: Human
Source: HEK293
Biological Activity: Immobilized mouse mFc-TNFSF11 at 10 μg/mL (100 μL/well) can bind human TNFRSF11B-His and the EC50 is 6.0-14.1 ng/mL. The bioactivity of hRANKL was determined by measuring the ability of hRANKL to induce TRAP activity in Raw 264.7 cells and the ED50 is 16 ng/mL.
研究背景:RANKL (TNFSF11) belongs to TNF family. RANKL is a type II transmembrane protein and is a receptor ligand for NF-κB (RANK). RANKL is an activator of NF-κB. RANKL binds to NF-κB and induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. In bone tissue, RANKL is expressed by osteoblasts, osteocytes and immune cells, especially in osteoblasts and osteocytes. RANKL is also expressed by T cells and increases proliferation and survival of dendritic cells.
Human RANKL shares 82.02% and 84.44% common aa identity with mouse and rat respectively. Human RANKL consists of cytoplasmic domain (1-47), helical domain (48-68), and extracellular domain (69-317). The soluble chain (140-317) is released when cleaved by enzymes such as matrix metalloproteinases (MMP3 or 7) and ADAM.
RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs).
蛋白编号:O14788-2 (G63-D244)
基因 ID:8600
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | 核因子-κB 受体激活因子配体 | CD 抗原 | T 细胞 CD 蛋白 | RANKL/CD254 | CD 抗原 | 巨噬细胞 CD 蛋白 | RANKL/CD254
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | RANKL | CD Antigens | T Cell CD Proteins | RANKL/CD254 | CD Antigens | Macrophage CD Proteins | RANKL/CD254
货号: HY-P73682
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