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MCE 国际站:IL-10 Protein, Mouse (CHO)
IL-10 Protein, Mouse (CHO)是一种有效的 CHO 细胞来源的抗炎细胞因子,作用于感染了神经性冠状病毒的小鼠,增强免疫介导的脱髓鞘作用。
Synonyms: rMuIL-10; CSIF
Species: Mouse
Source: CHO
Biological Activity: The ED50 is <0.2 ng/mL as measured by MC/9 cells.
研究背景:The anti-inflammatory cytokine interleukin-10 (IL-10) is a pleiotropic cytokine that is produced in abundant quantities during most parasitic, bacterial, viral, and fungal diseases. IL-10 functions by dampening the innate or very early T cell immune response. Treatment with IL-10 may be useful adjunct therapy in some types of viral encephalitis. IL-10 primarily acts to suppress macrophages and dendritic cell (DC) function by inhibiting expression of major histocompatibility complex (MHC) class II and costimulatory molecules such as CD80/CD86 and production of proinflammatory cytokines and chemokines, including IL-12. IL-10 also has direct effects on T cells, inhibiting activation and cytokine expression. Production of IL-10 by highly activated virus-specific T cells raises the possibility that IL-10 functions via both autocrine and paracrine signaling to limit inflammation during acute phases of the disease.
蛋白编号:P18893 (S19-S178)
基因 ID:16153
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-10
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-10
货号: HY-P7074A
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