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MCE 国际站:BAFFR/TNFRSF13C Protein, Mouse (HEK293, Fc)
BAFF Receptor (B-cell activating factor receptor,BAFF-R),又名 TNFRSF13C 和BR3,是识别 BAFF 的 TNF 受体超家族的一种膜蛋白。BAFF Receptor 是 B 细胞存活的关键受体,也是 B 细胞和 T 细胞活化的有效共刺激因子。BAFFR/TNFRSF13C Protein, Mouse (HEK293, Fc) 是一种由 HEK293 细胞表达的重组蛋白,其 C 末端带有 His 标签,由 62 个 (S10-A71) 氨基酸组成。
Synonyms: rMuBAFFR/TNFRSF13C, C-Fc; BAFF R; BAFFR; BR3; CD268; TNFRSF13C
Species: Mouse
Source: HEK293
Biological Activity: Immobilized Human BAFF-His at 10μg/mL (100 μL/well) can bind recombinant Mouse BAFFR/TNFRSF13C, C-Fc (HEK293-expressed). The ED50 of recombinant Mouse BAFFR/TNFRSF13C, C-Fc (HEK293-expressed) is 0.04ug/mL.
研究背景:BAFF Receptor is expressed on all B cells (except plasma cells), including immature, transitional, mature, memory, and germinal center B cells, as well as on plasma cells, while BAFF-R is also expressed on follicular helper T cells (TFH).
The amino acid sequence of human BAFF Receptor protein has low homology for mouse and rat BAFF Receptor protein.
BAFF Receptor binds to BAFF and recruits TNF receptor-associated factor 3 (TRAF-3) and TRAF-2 to the intracellular domain of BAFF-R molecules. The binding of TRAF3 to the BAFF-R reverses the inhibitory effect of unbound/cytoplasmic TRAF3 on the alternative NF-κB2 signaling pathway. It releases NF-κB-inducing kinase (NIK), which phosphorylates inhibitor of κB kinase 1 (IKK1) leading to activation of non-canonical NF-κB. BAFF-R signaling is critical for peripheral B cell survival and differentiation, germinal center formation, plasma cell survival, and IgG and IgE class switching.
BAFF Receptor binds to BAFF mediates B-cell survival, proliferation, and differentiation, and involves in the formation of GCs in secondary follicles in murine models and tertiary lymphoid structures in autoimmune diseases. BAFF/BAFF-R signaling is crucial for primary B cell survival, differentiation and homeostasis. A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice.
蛋白编号:Q9D8D0 (S10-A71)
基因 ID:72049
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | B-细胞激活因子受体 | CD 抗原 | 巨噬细胞 CD 蛋白 | BAFF R/CD268
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | BAFF Receptor | CD Antigens | Macrophage CD Proteins | BAFF R/CD268
货号: HY-P7646
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