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MCE 国际站:IL-15R alpha Protein, Mouse (HEK293, hFc)
IL-15R alpha 是 IL-15 的高亲和力受体 (Kd: 100 pM)。IL-15R alpha 与 IL-15 结合,从而激活 NK 细胞和 CD8+ T 细胞的抗肿瘤能力。IL-15R alpha 在维持记忆 CD8 T 细胞的稳态和淋巴细胞的发育中发挥着重要作用。IL-15R alpha Protein, Mouse (HEK293, hFc) 是一种由 HEK293 细胞产生的重组小鼠 IL-15R alpha 的胞外片段 (G33-K205),其 C 末端带有 hFc 标签。
Synonyms: Il15ra; Interleukin-15 receptor subunit alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; CD antigen CD215; Soluble interleukin-15 receptor subunit alpha; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA;
Species: Mouse
Source: HEK293
Biological Activity: Measured by its ability to block human IL-15-induced proliferation of CTLL-2 mouse cytotoxic T cells.The ED50 for this effect is <10 ng/mL.
研究背景:IL-15R alpha is expressed on various cell types, including lymphocytes, myeloid cells, nonlymphoid and nonhematopoietic cells. IL-15R alpha is down-regulated in Epstein-Barr virus associated gastric cancer (EBVaGC) via promoter hypermethylation.
The sequence of amino acids in IL-15R alpha differs in different species. Mouse IL-15R alpha shares <55% aa sequence identity with human.
IL-15R alpha is required for transporting of IL-15 from the endoplasmic reticulum to the cell surface to bind with β (CD122) and γ (CD132) chains on responding lymphocytes. When binding with IL-15, the complex increases the in vivo half-life of IL-15 and enhances binding affinity of IL-15 with IL-15Rβ/γ in NK cells and CD8+ T cells. Thus, the signal transmission improves proliferation and antitumor activities of NK cells and CD8+ T cells. Moreover, IL-15R alpha on the cancer cell surface induces the malignant phenotype, such as augmented cancer cell growth, migration and invasion, and decreased apoptosis. IL-15R alpha mediates immune responses, and is important for lymphocyte activation and proliferation, NK cell survival and proliferation.
IL-15R alpha binds with IL-15 and activates the antitumor functions of NK cells and CD8+ T cells, and is also important in memory CD8 T cell homeostasis and lymphocyte development.
蛋白编号:Q60819 (G33-K205)
基因 ID:16169
产品分类:细胞因子和生长因子 | 白细胞介素 | 白介素-15 受体 | 白介素-15 受体 α | CD 抗原 | NK 细胞 CD 蛋白 | CD215/IL-15R alpha
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-15 Receptor | IL-15R alpha | CD Antigens | NK Cell CD Proteins | CD215/IL-15R alpha
货号: HY-P71978
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