MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

IL-1 alpha Protein, Human

MCE 国际站：IL-1 alpha Protein, Human

IL-1 alpha 是一种普遍存在的关键促炎细胞因子。IL-1 alpha 由单核细胞和巨噬细胞作为前蛋白产生，它经过蛋白水解加工并响应细胞损伤而释放，从而诱导细胞凋亡。IL-1 alpha 在炎症中发挥重要作用，并连接先天免疫和适应性免疫系统。IL-1 alpha 介导 NF-kappa-B 和三种 MAPK 途径 (p38、p42/p44、JNK) 的激活。IL-1 alpha protein, Human 是重组蛋白, 由 159 个 (S113-A271) 氨基酸组成，在大肠杆菌中表达。

Synonyms: rHuIL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha

Species: Human

Source: E. coli

Biological Activity: 1.The ED₅₀ is <1.0 pg/mL as measured by murine D10S cells, corresponding to a specific activity of >1.0 × 10⁹ units/mg.
2.Measured in a cell proliferation assay using CTLL-2 cells. The ED₅₀ for this effect is 10.95 pg/mL,corresponding to a specific activity is 91.32×10⁶ units/mg

研究背景：IL-1 alpha (interleukin-1 alpha) is a major agonist of IL-1. IL-1α is present in all mesenchymal cells in particular, cells rich in IL-1α constitute tissues with a barrier function, such as keratinocytes in the skin, type 2 epithelial cells in the lung, the epithelium of the entire gastrointestinal tract, endothelial cells in blood vessels, and astrocytes in the brain. The precursor of IL-1α (ProIL-1α) is processed by the Ca²⁺-dependent protease calpain (including caspase-1) into the mature 17 kDa form and the 16 kDa N-terminal cleavage product – the propiece of IL-1α, also termed IL-1α N-terminal peptide (IL-1NTP). The latent form of calpain is activated in cells under inflammatory conditions and especially upon loss of plasma membrane integrity, which occurs during necrosis. pro-IL-1α and mature IL-1α bind to IL-1R and induces the secretion of IL-6 and TNF.IL-1α acts as an ‘alarmin’ and as a primum movens of tissue inflammation. IL-1 alpha trigger inflammation in a pathway initiated through Myd88 activation and culminated in NF-κB–induced transcription of inflammatory genes. IL-1 alpha inhibits differentiation of preadipocytes and lipid accumulation. IL-1 alpha induces apoptosis and inhibits the osteoblast differentiation.

蛋白编号：P01583 (S113-A271)

基因 ID：3552

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-1  |  白细胞介素-1 alpha  |  细胞因子和生长因子  |  神经营养因子  |  白细胞介素-1  |  白细胞介素-1 alpha

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-1  |  IL-1 alpha  |  Cytokines and Growth Factors  |  Neurotrophic Factors  |  IL-1  |  IL-1 alpha

货号: HY-P7027

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。