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PEDF Protein, Human

MCE 国际站：PEDF Protein, Human

PEDF Protein, Human是分泌糖蛋白，是丝氨酸蛋白酶抑制剂（丝氨酸蛋白酶抑制剂）家族的非抑制成员。

Synonyms: rHuPEDF; SerpinF1; EPC-1

Species: Human

Source: E. coli

Biological Activity: The ED₅₀ is <2 ng/mL as measured by human Saos2 cells, corresponding to a specific activity of >5.0 × 10⁵ units/mg.

研究背景：Pigment Epithelium-derived Factor belongs to the serine protease inhibitor (serpin) family. The Pigment Epithelium-derived Factor gene contains a typical signalpeptide sequence, initiator methionine codon, and polyadenylylation signal and matches the size of other members of the serpin superfamily. Pigment Epithelium-derived Factor is a neurotrophic agent. It is widely expressed in human fetal and adult tissues but its expression decreases with age and in malignant tissues. The main anticancer activities of Pigment Epithelium-derived Factor derive from its dual effects, either indirectly on the tumor microenvironment (indirect antitumor action) or directly on the tumor itself (direct antitumor influence). Pigment Epithelium-derived Factor has complex neurotrophic, neuroprotective, anti-angiogenic, anti-oxidative, and anti-inflammatory properties, and could potentially be exploited as a therapeutic option for the treatment of vascular complications in diabetes.

蛋白编号：P36955 (Q20-P418)

基因 ID：5176

产品分类：酶和调节子  |  蛋白酶抑制剂蛋白  |  丝氨酸蛋白酶抑制剂 Serpin  |  Pigment Epithelium Derived Factor

Categories：Enzymes & Regulators  |  Protease Inhibitors  |  Serpin (Protease Inhibitor)  |  Pigment Epithelium Derived Factor

货号: HY-P7054

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