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IL-17F Protein, Human

MCE 国际站：IL-17F Protein, Human

IL-17F 是一种炎性同型二聚体细胞因子，可诱导许多促炎细胞因子和趋化因子。IL-17F 也能诱导抗菌肽。IL-17F 在结肠癌发展中起保护作用，可用于自身免疫性疾病、感染和癌症的研究。IL-17F Protein, Human 是一种重组人 IL-17F 蛋白，在 E. coli 中表达，由 133 个氨基酸组成(R31-Q163)。

Synonyms: rHuIL-17F; Cytokine ML-1

Species: Human

Source: E. coli

Biological Activity: The ED₅₀ is <40 ng/mL as measured by murine NIH/3T3 cells, corresponding to a specific activity of >5.0 × 10⁴ units/mg.

研究背景：Interleukin-17F (IL-17F) belongs to the IL-17 cytokine family. IL-17F is expressed in activated CD4 T cells, activated monocytes, basophils and mast cells. IL-17F can be produced by differentiated TH17 cells, lamina propria T cells, memory CD4⁺ T cells, γδ T cells and NKT cells.
The human IL-17F shares 55.90% amino acid sequence identity with mouse and 57.14% identity with rat.
IL-17F is an inflammatory cytokine that induces many proinflammatory cytokines and chemokines, including TGF-β, IL-2, ICAM1, GM-CSF, CCL2, CCL7, TSLP, MMP13, IL-6 and CXCL1. IL-17F also induces antimicrobial peptides including hBD-2, S100A7, S100A8 and S100A9 with IL-22 and can synergize with IL-23 in human eosinophils to promote the production of IL-1β and IL-6. IL-17F is a homodimeric cytokine. IL-17F shares the most similarities with IL-17A (50% homology) and can be produced as an IL-17AF heterodimer. IL-17A, IL-17F and IL-17A/F use the same receptor complex: IL-17RA and IL-17RC heterodimer. They trigger qualitatively similar signaling pathways, and IL-17F exhibits the lowest biological activity. IL-17F shows about 100–1000 times lower affinity to the IL-17RA subunit than IL-17A, and does not compete with IL-17A binding to IL-17RA.
IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer.

蛋白编号：Q96PD4 (R31-Q163)

基因 ID：112744

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-17  |  白细胞介素-17F

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-17  |  IL-17F

货号: HY-P7209

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