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MCE 国际站:BAFF/TNFSF13B Protein, Human (HEK293, Fc)
BAFF/TNFSF13B,是激活B细胞的细胞因子,属于肿瘤坏死因子家族。BAFF 参与癌症免疫,主要在髓系细胞中表达。它的过度表达可导致自身免疫,如系统性红斑狼疮 (SLE)。此外,BAFF 还参与了脂肪形成、动脉粥样硬化、神经炎症过程和缺血再灌注 (I/R) 损伤。人的 BAFF 蛋白有 2 个糖基化结构域和 1 个跨膜结构域 (48-68 a.a.),可裂分为膜型肽片段和可溶性肽片段。重组人 BAFF/TNFSF13B 蛋白 (HEK293, His) 是 BAFF 蛋白的胞外部分 (A134-L285),由 HEK293 细胞表达,带有 N 端 hFc 标签。
Synonyms: Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1
Species: Human
Source: HEK293
研究背景:B-cell Activating Factor (BAFF), belongs to tumor necrosis factor family, also known as B lymphocyte stimulator (BLyS), dendritic cell-derived TNF-like molecule, and TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1). BAFF is the surpotor of autoreactive B cells, mainly expressed in myeloid cell lines. The expression level of BAFF is important with immunity, while excessive BAFF signaling can lead to autoimmunity. For example, BAFF is commonly overexpressed in Systemic Lupus Erythematosus (SLE). Furthermore, BAFF seems to be involved in adipogenesis, atherosclerosis, neuro-inflammatory processes and ischemia reperfusion (I/R) injury. DeltaBAFF is a conserved alternate splice isoform of BAFF, with a lack of 57 nt encoding the A-A1 loop. DeltaBAFF is co-expressed with BAFF in many mouse and human myeloid cells. DeltaBAFF in mouse is inefficiently released by proteolysis on plasma membrane, and binds to BAFF in heteromultimers to diminish BAFF bioactivity and release. Mouse BAFF protein has two glycosylated domains and one transmembrane domain (48-68 a.a.), and can be cleaved into membrane-type peptide fragments and soluble peptide fragments. Moreover, the protein sequences between human and mice are different with similarity of 68.23%. BAFF also involves in cancer immunity. BAFF upregulates multiple B cell costimulatory molecules; augments IL-12a expression and enhances B cell antigen-presentation to CD4+ Th cells in vitro. it also modulates T cell function through increased T cell activation and TH1 polarization, enhanced expression of the proinflammatory leukocyte trafficking chemokine CCR6, and promotion of a memory phenotype, leading to enhanced antitumor immunity. BAFF has distinct immunoregulatory functions, promoting the expansion of CD4+Foxp3+ Tregs in the spleen and tumor microenvironment (TME).
蛋白编号:Q9Y275 (A134-L285)
基因 ID:10673
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | B-细胞激活因子 | CD 抗原 | B 细胞 CD 蛋白 | CD257/BAFF | CD 抗原 | 巨噬细胞 CD 蛋白 | CD257/BAFF
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | B-cell Activating Factor (BAFF) | CD Antigens | B Cell CD Proteins | CD257/BAFF | CD Antigens | Macrophage CD Proteins | CD257/BAFF
货号: HY-P70730
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