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CCL4 Protein, Human

MCE 国际站：CCL4 Protein, Human

CCL4 Protein, Human 是一种 CC 趋化因子亚家族的小细胞因子，可以与细胞表面的 CCR5 趋化因子受体结合作用。能够在各种炎症条件下促进白细胞聚集，又有助于对人类免疫缺陷 1 型病毒产生免疫保护。CCL4 Protein, Human 是由 E. coli 表达的重组人 CCL4 (A24-N92)。

Synonyms: rHuMIP-1β/CCL4; C-C motif chemokine 4; LAG-1; Macrophage inflammatory protein 1-beta; SCYA4

Species: Human

Source: E. coli

Biological Activity: 1. The ED₅₀ is <100 ng/mL as measured by CHO-K1/Gα15/hCCR5 cells (human Gα15 and human CCR5 stably expressed in CHO-K1 cells).
2. Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED₅₀ this effect is 2.785 ng/mL, corresponding to a specific activity is 3.59×10⁵ U/mg.

研究背景：CCL4, also known as macrophage inflammatory protein (MIP-1β), belongs to the CC chemokine family and is a protein encoded in humans by the CCL4 gene, which belongs to the 17q11-q21 region of chromosome 17 and has a molecular weight of approximately 8-10 kDa. CCL4 can be produced by monocytes, B cells, T cells, NK cells, dendritic cells, neutrophils, fibroblasts, endothelial cells, and epithelial cells. CCL4 acts as a chemokine that binds to the G protein-coupled receptors CCR5 and CCR8 and acts as a chemoattractant for natural killer cells, monocytes and various other immune cells at sites of inflammation or damaged tissues. In parallel, CCL4 can also act as a major HIV suppressor produced by CD8+ T cells, inducing dose-dependent inhibition of different strains of HIV-1, HIV-2 and monkey immunodeficiency virus (SIV). Among them, the N-terminal processed form CCL4 (3-69), produced by proteolytic cleavage of peripheral blood lymphocytes after secretion, retains the ability to induce down-regulation of chemokine receptor CCR5 surface expression and inhibit CCR5-mediated HIV-1 entry into T cells.

蛋白编号：P13236 (A24-N92)

基因 ID：6351

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL4

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  MIP-1 beta/CCL4

货号: HY-P7257

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