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Exodus-2/CCL21 Protein, Human (sf9)

MCE 国际站：Exodus-2/CCL21 Protein, Human (sf9)

Exodus-2/CCL21 Protein, Human (sf9) 是一种稳态淋巴样趋化因子，有助于 T 细胞和树突状细胞进入淋巴样 T 区。可通过趋化因子受体 CCR7 和 CXCR3 发挥作用，促进纤维化和炎症细胞因子的产生。Exodus-2/CCL21 Protein, Human (sf9) 是一种由 Sf9 insect cells 表达的重组人 Exodus-2/CCL21(S24-P134)。

Synonyms: C-C motif chemokine 21; Beta-chemokine exodus-2; 6Ckine; SLC; CCL21; SCYA21

Species: Human

Source: Sf9 insect cells

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Exodus-2/CCL21 Protein, Human (sf9) at 2 μg/mL (100 μl/well) can bind human IGFBP7 with a linear range of 0.16-4 μg/mL.

研究背景：CCL21, also known as exodus-2 and secondary lymphoid chemokine (SLC), is a small cytokine belonging to the CC chemokine family and is located on chromosome 9 in the human genome. It binds to glycosaminoglycan (GAG) and is anchored to the surface of endothelial cells. As a chemokine, CCL21 inhibits hematopoiesis and stimulates chemotaxis, and is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages or neutrophils. At the same time, CCL21 is a potent stimulator of T cell migration and adhesion, binding to the glycoprotein PSGL-1 on T cells to promote the migration of T cells to secondary lymphoid organs. CCL21 can act through chemokine receptors CCR7 and CXCR3. Among them, CCR7 is a GPCR that is normally expressed by T cell subsets central memory cells, thymic T cells, B cells, mature DCs and other rare cell subsets. ccl21 can function as a microglia activator in the CNS and is expressed exclusively in endangered or mechanically damaged neurons.

蛋白编号：O00585 (S24-P134)

基因 ID：6366

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL21

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  CCL21

货号: HY-P72875

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