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IL-27 Protein, Human (CHO, His)

MCE 国际站：IL-27 Protein, Human (CHO, His)

IL-27 (Interleukin-27) 是 IL-12 家族的异二聚体细胞因子，由 EBI3 (Epstein-Barr-virus-induced 分子 3) 和 p28 两个亚基组成。IL-27增强CD8⁺ T 细胞的发育、增殖和细胞毒活性，从而间接促进抗肿瘤免疫。IL-27 Protein, Human (CHO, His) 是一种重组蛋白，C 端带有 His 标签，由 EBI3 (IL27B) (229 个氨基酸 (M1-K229)) 和 IL27 (IL27A, IL30) (214 个氨基酸 (F29-P243)) 组成，在 CHO 细胞中表达。

Synonyms: Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

Species: Human

Source: CHO

Biological Activity: Measured in antiviral assays using HepG2 cells infected with vesicular stomatitisvirus(VSV) and the ED₅₀ is 10 ng/mL.

研究背景：IL-27 is mainly produced by cells of myeloid origin such as monocytes, macrophages, dendritic cells, and microglial cells, in response to stimuli acting through Toll-like receptors or TNF-R-family members.
The amino acid sequence of human IL-27 protein has low homology for mouse IL-27 protein.
IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1) and gp130 chains, activates the JAK/STAT signaling pathway, which mainly involves STAT1 and STAT3 phosphorylation. STAT3 activation by IL-27 induces the expression of SOCS3, which inhibits further IL-27 signaling in a negative feedback loop, through inhibition of JAK activity.
IL-27 plays multiple roles in proinflammatory and anti-inflammatory immune responses. IL-27 enhances NF-κB/AP-1 activity and increases IL-12p40, TNF-α, and IL-6 production, increases TLR4 and TLR5 expression. IL-27 exerts inhibitory effects upon hPMSC adherence and proliferation, and promotes migration of hPMSCs. Besides, IL-27 can upregulate PDL1 expression and enhance the regulatory effects of hPMSCs on Th1 and Th2 cell differentiations and IL-10 secretion from CD4+T cells. IL-27 induces the proliferation and differentiation in hematopoietic stem cells. IL-27 increases IL-10 levels and the expression of p-STAT1, p-STAT3. IL-27 promotes the development and differentiation of CD4+IL-10+ T cells.

蛋白编号：Q14213 (R21-K229)&Q8NEV9 (F29-P243)

基因 ID：10148& 246778

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-27

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-27

货号: HY-P73199

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