MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Follistatin/FST Protein, Mouse (CHO, Fc)

MCE 国际站：Follistatin/FST Protein, Mouse (CHO, Fc)

Follistatin (FST) 是 TGFβ 家族信号传导的调节剂，通过选择性结合 TGFβ 家族配体并阻止配体与受体复合物结合而发挥作用。Follistatin 具有抑制促卵泡激素 (FSH) 的能力。Follistatin/FST Protein, Mouse (CHO, Fc) 在 CHO 细胞中表达产生，由 317 个氨基酸(M1-N317) 组成，在 C 末端带有 Fc 标签。

Synonyms: Follistatin; FS; Activin-binding protein; FST

Species: Mouse

Source: CHO

Biological Activity: Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation and the ED₅₀ is typically 40-200 ng/mL in the presence of 10 ng/mL rhActivin A.

研究背景：Follistatin is first described as a follicle-stimulating hormone inhibiting substance present in ovarian follicular fluid. Follistatin binds activin A and myostatin with low nanomolar (nM) affinity, completely surrounds the ligand occluding all of the receptor binding sites and binds to the ligand.
Mature human Follistatin shares 97% amino acid sequence identity with mouse and rat Follistatin.
Follistatin is a 32-35-kDa glycoprotein composed of four domains including an N-terminal domain (ND) followed by three Follistatin domains (FSD1, FSD2, and FSD3). C-terminal splicing of Follistatin can occur to generate various isoforms including FS288 and FS315. Follistatin neutralizes the TGFβ ligands, myostatin and activin A, by forming a nearly irreversible non-signaling complex by surrounding the ligand and preventing interaction with TGFβ receptors. In humans, the gene encoding Follistatin is located on chromosome 5q11.2. The Follistatin protein contains a TGF-β binding site where activins, bone morphonegic proteins (BMPs) and growth differentiation factors (GDFs) are bound with high affinity and thereby neutralised. The ligand binding site for Follistatin overlaps with the type I and type II receptor binding sites for these ligands. Follistatin also contains a heparin binding site where proteoglycans in the extracellular matrix can bind, and therefore Follistatin is believed to bind the extracellular matrix. There are two major isoforms of Follistatin, FST288, which is anchored to the cell surface by interactions with heparin sulfate proteoglycans, and FST315, which is the predominant form found in circulation. The two isoforms arise from alternative splicing; the 315 isoform includes a 27 amino acid acidic C-terminal tail, which Follistatin 288 does not have. The acidic tail on Follistatin 315 neutralises the heparin binding site, thereby inhibiting the binding of Follistatin 315 to the extracellular matrix.
Follistatin as a liver-derived protein under the regulation of glucagon-to-insulin ratio suggests a relation to energy metabolism. In humans, aberrant expression of FST and activins are implicated in infertility. Follistatin is a potent tissue regulator in the gonad, pituitary gland, pregnancy membranes, vasculature, and liver.

蛋白编号：P47931 (M1-N317)

基因 ID：14313

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  Activin/Inhibins Receptor  |  激活素结合蛋白

Categories：Cytokines and Growth Factors  |  TGF-beta Superfamily  |  Activin/Inhibins Receptor  |  Follistatin

货号: HY-P74148

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。