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FGF-21 Protein, Human (181aa)

MCE 国际站：FGF-21 Protein, Human (181aa)

FGF-21 Protein, Human是一个非典型的成纤维细胞生长因子 (FGF)，作为代谢调节剂，具有多重效应。

Synonyms: rHuFGF-21; Fibroblast Growth Factor-21(FGF-21)

Species: Human

Source: E. coli

Biological Activity: Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is 1.071 μg/ml in the presence of 1.25 μg/mL Recombinant Human Klotho beta, corresponding to a specific activity is 933.7068 units/mg.

研究背景：Human Fibroblast Growth Factor 21 (FGF21) acts in an endocrine mannerand and is a metabolic regulator with pleiotropic effects. FGF21 possesses protective effects in the cardiovascular system, primarily due to metabolic effects other thanmaintaining energy homoeostasis. FGF21 is also involved inseveral processes, including reducing arteriosclerotic plaque formation in major vessels and protecting themyocardium from injuries caused by infarction, ischaemia-reperfusion, isoproterenol-induced hypertrophy anddiabetic lipotoxicity. In addition, FG2F1 induces these effects by atten-uating remodelling-related inflammation and oxidativestress and promoting myocardial energy metabolism, as well as by preventing lipid- or diabetes-induced cardiaccell apoptosis. FGF21 functions via its interaction with FGF receptors (FGFRs), with the assistance of the co-receptor β-Klotho. Structurally, the FGFRs are divided into four isoforms, FGFR1-FGFR4.

蛋白编号：Q9NSA1 (H29-S209)

基因 ID：26291

货号: HY-P701092

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