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MCE 国际站:IL-1 alpha Protein, Rat (CHO)
IL-1 alpha 是一种普遍存在的关键促炎细胞因子。IL-1 alpha 由单核细胞和巨噬细胞作为前蛋白产生,它经过蛋白水解加工并响应细胞损伤而释放,从而诱导细胞凋亡。IL-1 alpha 在炎症中发挥重要作用,并连接先天免疫和适应性免疫系统。IL-1 alpha 介导 NF-kappa-B 和三种 MAPK 途径 (p38、p42/p44、JNK) 的激活。IL-1 alpha Protein, Rat (CHO) 是重组蛋白, 由 155 个 (S116-A270) 氨基酸组成,在 CHO 细胞中表达。
Synonyms: rRtIL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha
Species: Rat
Source: CHO
Biological Activity: The ED50 is <5 pg/mL as measured by D10S cells.
研究背景:IL-1 alpha (interleukin-1 alpha) is a major agonist of IL-1. IL-1α is present in all mesenchymal cells in particular, cells rich in IL-1α constitute tissues with a barrier function, such as keratinocytes in the skin, type 2 epithelial cells in the lung, the epithelium of the entire gastrointestinal tract, endothelial cells in blood vessels, and astrocytes in the brain. The precursor of IL-1α (ProIL-1α) is processed by the Ca2+-dependent protease calpain (including caspase-1) into the mature 17 kDa form and the 16 kDa N-terminal cleavage product – the propiece of IL-1α, also termed IL-1α N-terminal peptide (IL-1NTP). The latent form of calpain is activated in cells under inflammatory conditions and especially upon loss of plasma membrane integrity, which occurs during necrosis. pro-IL-1α and mature IL-1α bind to IL-1R and induces the secretion of IL-6 and TNF.IL-1α acts as an ‘alarmin’ and as a primum movens of tissue inflammation. IL-1 alpha trigger inflammation in a pathway initiated through Myd88 activation and culminated in NF-κB–induced transcription of inflammatory genes. IL-1 alpha inhibits differentiation of preadipocytes and lipid accumulation. IL-1 alpha induces apoptosis and inhibits the osteoblast differentiation.
蛋白编号:P16598-1 (A116-S270)
基因 ID:24493
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-1 | 白细胞介素-1 alpha | 细胞因子和生长因子 | 神经营养因子 | 白细胞介素-1 | 白细胞介素-1 alpha
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-1 | IL-1 alpha | Cytokines and Growth Factors | Neurotrophic Factors | IL-1 | IL-1 alpha
货号: HY-P7096
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