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MCE 国际站:G-CSF Protein, Human
G-CSF Protein, Human 是一种糖蛋白,能够刺激粒细胞生成,先天免疫的产生,以及神经前体细胞的分化。
Synonyms: Granulocyte Colony-Stimulating Factor; G-CSF; Pluripoietin; Filgrastim; Lenograstim; CSF3; C17orf33; GCSF
Species: Human
Source: E. coli
Biological Activity: Measured in a cell proliferation assay using NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 25.28 pg/mL, corresponding to a specific activity is 3.96×10^7 units/mg.
研究背景:G-CSF is a glycoprotein, secreted by the cells of the immune system, fibroblasts, and endothelium and functions to stimulate granulopoiesis, the innate immunity, and the differentiation of neural progenitor cells. G-CSF conveys neuroprotection to central neurons upon increases in phosphorylation of PI3K/Akt pathway, and regulates epithelial to mesenchymal transition in cancer. G-CSF acts via a specific cognate receptor (G-CSFR) that belongs to the class I cytokine receptor superfamily. G-CSF is well known as a hematopoietic cytokine that stimulates the proliferation, differentiation, and function of myeloid progenitors and mobilization of hematopoietic stem and progenitor cells. G-CSF has the potential to inhibit the progression of atherosclerosis in animal models.
蛋白编号:P09919-2 (T31-P204)
基因 ID:1440
产品分类:细胞因子和生长因子 | 集落刺激因子 | 粒细胞集落刺激因子
Categories:Cytokines and Growth Factors | CSF & Receptors | G-CSF
货号: HY-P70422
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