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MCE 国际站:TECK/CCL25 Protein, Human
TECK/CCL25 Protein, Human 是一种 CC 趋化因子,可以与趋化因子受体 CCR9 结合作用,参与 T 细胞的发育和细胞迁移小肠的过程,以及多种炎症性疾病并促进炎症反应。对胸腺细胞、巨噬细胞和树突细胞具有趋化作用。TECK/CCL25 Protein, Human 是一种由 E. coli 表达的重组人 TECK/CCL25(Q24-L150) 蛋白。
Synonyms: rHuTECK/CCL25; C-C motif chemokine 25; SCYA25
Species: Human
Source: E. coli
Biological Activity: Full biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml.
研究背景:CCL25, also known as thymus-expressing chemokine TECK, a small cell factor of the CC chemokine family, is located on chromosome 19 in the human genome. CCL25 is mainly expressed in the thymus and intestinal epithelium, but can also be produced by parenchymal cells such as vascular endothelial cells, which can migrate immature T cells to the thymus for mature release. It is chemotactic for thymocytes, macrophages and dendritic cells and can act in combination with the chemokine receptor CCR9. Among others, CCR9 is found as a G protein-coupled receptor expressed on the cell membranes of dendritic cells, neutrophils, lymphocytes, monocyte macrophages and vascular endothelial cells. CCR9 belongs to the β-chemokine receptor family and the gene is located on chromosome 3 at p21.31. CCL25-CCR9 is involved in the development of T cells and cell migration to the small intestine, as well as in a variety of inflammatory diseases and promotes inflammatory responses, including cardiovascular disease (CVD), hepatitis, and arthritis. The interaction of CCL25 with CCR9 also supports T cell survival during thymic maturation by inhibiting apoptosis through Akt/protein kinase B activation.
蛋白编号:O15444 (Q24-L150)
基因 ID:6370
产品分类:细胞因子和生长因子 | 趋化因子 | CC 趋化因子 | 趋化因子 CCL25
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CC Chemokines | CCL25
货号: HY-P7294
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