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TWEAK/TNFSF12 Protein, Human (CHO)

MCE 国际站：TWEAK/TNFSF12 Protein, Human (CHO)

TWEAK 蛋白是细胞因子肿瘤坏死因子样细胞凋亡弱诱导因子，属于肿瘤坏死因子 (TNF) 超家族。TWEAK 蛋白与 FN14 和 TNRFSF12/APO3 结合，是细胞凋亡的弱诱导因子。TWEAK 蛋白对肿瘤细胞有促凋亡活性，可介导 NF-kappa-B 的激活，促进血管生成和内皮细胞 (ECs) 增殖。TWEAK 蛋白还能增加 IL-6 和 IL-8 的分泌，增强 TNF 和 IL-1 的促炎活性。人的 TWEAK 蛋白 (M1-H249) 是一种 II 型跨膜糖蛋白，含有一个跨膜结构域 (22-42 a.a.)。重组人 TWEAK/TNFSF12 蛋白 (CHO) 是 TWEAK 蛋白的胞外部分 (R99-H2499)，由 CHO 细胞表达，不带标签。

Synonyms: rHuTWEAK; TNF-related weak inducer of apoptosis; TNFSF12; DR3LG; APO3L

Species: Human

Source: CHO

Biological Activity: The ED₅₀ is <1 ng/mL as measured in a cell cytotoxicity assay using HTB-38 (HT-29) cells.

研究背景：TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis. It is a multifunctional cytokine belonging to tumor necrosis factor (TNF) superfamily, acts function by binding TweakR/Fn14 receptor. TWEAK is a cell surface-associated type II transmembrane protein with 2 types protein chain: the membrane form and the secreted or soluble form. The soluble form derives from the membrane form by proteolytic processing. The protein sequences in human and mouse is very different with similarity of 24.79%.
TWEAK binds to FN14 and possibly also to TNRFSF12/APO3, is a weak inducer of apoptosis in some cell types. TWEAK mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells.
TWEAK has multiple biological activities, many of which are associated with immune system development and function.
TWEAK does have pro-apoptotic activity on a select group of human tumor cell lines and on monocytes, while it promotes cell proliferation in human vascular EC and SMC. Furthermore, FGF-2 co-treatment can potentiate TWEAK-stimulated HUVEC proliferation, an effect that may be due to the ability of FGF-2 to up-regulate TweakR/Fn14 gene expression. At the meanwhile TWEAK-TweakR/Fn14 autocrine signaling promotes human microvascular renal EC (HMREC) migration.
TWEAK also plays key role in inflammatory response. TWEAK, stimulates interleukin (IL)-8 secretion in human tumor cell lines, WI-38 fibroblasts and astrocytes. TWEAK also increases IL-6 secretion and ICAM-1 expression in astrocyte cell. Moreover, TWEAK co-incubation could potentiate the pro-inflammatory activities of TNF and IL-1, and concluded that TWEAK could be involved in the pathogenesis of chronic inflammatory diseases.
Above all, TWEAK involves in stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, and under some experimental conditions, stimulation of apoptosis.

蛋白编号：O43508 (R99-H249)

基因 ID：8742

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  TWEAK 蛋白

Categories：Cytokines and Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  TWEAK Proteins

货号: HY-P7309

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