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MIP-2/CXCL2 Protein, Mouse

MCE 国际站：MIP-2/CXCL2 Protein, Mouse

CXCL2，也称为Gro-beta 或 MIP-2，是一种促炎细胞因子，对中性粒细胞具有趋化活性。CXCL2 由活化的单核细胞和中性粒细胞产生并在炎症部位表达。CXCL2 参与许多免疫反应，包括伤口愈合、癌症转移和血管生成。MIP-2/CXCL2 Protein, Mouse 是在大肠杆菌中表达产生的，由 74 个氨基酸组成(A27-N100)。

Synonyms: rMuMIP-2/CXCL2; C-X-C motif chemokine 2; SCYB2

Species: Mouse

Source: E. coli

Biological Activity: 1. The ED₅₀ is <1 ng/mL as measured by CHO-K1/Gα15/mCXCR2 cells (human Gα15 and mouse CXCR2 stably expressed in CHO-K1 cells).
2. Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED₅₀ this effect is 24.09 ng/ml, corresponding to a specific activity is 41511 units/mg.

研究背景：CXCL2 is a chemokine induced by endotoxin and serves as an extremely potent chemo-attractant for neutrophils, acting as a crucial inflammatory mediator. CXCL2 could be produced by multiple, different cell types, including macrophages and cancer cells. CXCL2 is involved in cancer metastasis, angiogenesis, and wound healing.
The amino acid sequence of human CXCL2 protein has low homology between mouse and rat CXCL2 protein.
CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 binds to the G-protein coupled receptor CXCR2 (IL-8RB) expressed on macrophages, neutrophils, and epithelial cells and its classical function is to act as chemotactic factors attracting neutrophils to sites of injury.
In enterocytes, LPS induces CXCL2 expression and promotes migration of neutrophils in a model of platelet-activating factor induced shock and bowel injury. In acute lung injury, CXCR2 ligands, including CXCL1/2/3, have chemotactic effects for polymorphonuclear leukocytes. CXCL2 could provoke a dose-dependent increase of colorectal tumor cell migration in vitro. Further, according to Bachmeier et al., CXCL-1 and −2 silencing could down-regulate several metastasis-promoting genes and inhibit the metastatic potential of breast cancer cells.

蛋白编号：P10889 (G27-N100)

基因 ID：20310

产品分类：细胞因子和生长因子  |  趋化因子  |  CXC 趋化因子  |  CXC 趋化因子配体 2

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CXC Chemokines  |  MIP-2/GRO-beta

货号: HY-P7258

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